Expedient protocol for solid-phase synthesis of secondary and tertiary amines

Christian A Olsen, Matthias Witt, Jerzy W Jaroszewski, Henrik Franzyk

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23 Citations (Scopus)

Abstract

[reaction: see text] An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.
Original languageEnglish
JournalOrganic Letters
Volume6
Issue number12
Pages (from-to)1935-8
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 2004

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