Experimental candidosis in pregnant mice

H. E. Jensen*, J. Hau, B. AalbæK, H. SchØNheyder

*Corresponding author for this work

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6 Citations (Scopus)

Abstract

Pregnant mice were challenged intravenously with doses of 1 × 103 ‐ 1 × 107Candida albicans blastospores, and from postmortem histopathology it was found that C. albicans had a propensity for localization in the murine placenta. At the highest dose, blastospores, hyphae and pseudohyphae were randomly located in the foeto‐placental units, whereas proliferation of fungi at lower doses started in the rim of the placental disc, after which it spread along Reichert's membrane and/or the splanchnopleure, eventually attacking the foetal skin. These findings are analogous to our previous observations on the nature of Aspergillus fumigatus infection in pregnant mice. 1991 Acta Pathologica, Microbiologica et Immunologica Scandinavica

Original languageEnglish
JournalAPMIS
Volume99
Issue number7-12
Pages (from-to)829-835
Number of pages7
ISSN0903-4641
DOIs
Publication statusPublished - Jul 1991

Keywords

  • Candidosis
  • murine model
  • mycotic placentitis

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