TY - JOUR
T1 - Experimental Infection in Mice with Bacillus licheniformis
AU - Agerholm, J. S.
AU - Jensen, H. E.
AU - Jensen, N. E.
PY - 1995
Y1 - 1995
N2 - The pathogenicity of Bacillus licheniformis was assessed in normal and immunodepressed BALB/c mice. The animals were challenged intravenously with 4 times 107 colony forming units of B. licheniformis (ATCC 14580) and both normal and immunodepressed mice were susceptible. However, the infection was more severe in the immunosuppressed animals. In normal mice, lesions were restricted to the liver and kidneys, while lesions also occurred in other organs of immunodepressed mice. By crossed immunoelectrophoresis it was shown that antigens of B. licheniformis are potent immunogens, and the bacteria could be identified in tissue sections by immunostaining. Immunohistochemically, B. licheniformis was demonstrated in hepatic and pulmonic macrophages, and from some animals the bacteria were also reisolated.
AB - The pathogenicity of Bacillus licheniformis was assessed in normal and immunodepressed BALB/c mice. The animals were challenged intravenously with 4 times 107 colony forming units of B. licheniformis (ATCC 14580) and both normal and immunodepressed mice were susceptible. However, the infection was more severe in the immunosuppressed animals. In normal mice, lesions were restricted to the liver and kidneys, while lesions also occurred in other organs of immunodepressed mice. By crossed immunoelectrophoresis it was shown that antigens of B. licheniformis are potent immunogens, and the bacteria could be identified in tissue sections by immunostaining. Immunohistochemically, B. licheniformis was demonstrated in hepatic and pulmonic macrophages, and from some animals the bacteria were also reisolated.
UR - http://www.scopus.com/inward/record.url?scp=0029312947&partnerID=8YFLogxK
U2 - 10.1111/j.1439-0450.1995.tb00708.x
DO - 10.1111/j.1439-0450.1995.tb00708.x
M3 - Journal article
C2 - 8546023
AN - SCOPUS:0029312947
VL - 42
SP - 247
EP - 256
JO - Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health
JF - Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health
SN - 0931-1793
IS - 1-10
ER -