TY - JOUR
T1 - Exposure to different residential indoor characteristics during childhood and asthma in adolescence
T2 - a latent class analysis of the Danish National Birth Cohort
AU - Keller, Amélie
AU - Groot, Jonathan
AU - Clippet-Jensen, Clara
AU - Pinot de Moira, Angela
AU - Pedersen, Marie
AU - Sigsgaard, Torben
AU - Loft, Steffen
AU - Budtz-Jørgensen, Esben
AU - Nybo Andersen, Anne Marie
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024
Y1 - 2024
N2 - Background: Many residential indoor environments may have an impact on children’s respiratory health. Objectives: The aims of this study were to identify latent classes of children from the Danish National Birth Cohort (DNBC) who share similar patterns of exposure to indoor home characteristics, and to examine the association between membership in the latent classes and asthma in adolescence. Methods: We included data on residential indoor characteristics of offspring from the DNBC whose mothers had responded to the child’s 11-year follow-up and who had data on asthma from the 18-year follow-up. Number of classes and associations were estimated using latent class analysis. To account for sample selection, we applied inverse probability weighting. Results: Our final model included five latent classes. The probability of current asthma at 18 years was highest among individuals in class one with higher clustering on household dampness (9, 95%CI 0.06–0.13). Individuals in class four (with higher clustering on pets ownership and living in a farm) had a lower risk of current asthma at age 18 compared to individuals in class one (with higher clustering on household dampness) (OR 0.53 (95%CI 0.32–0.88), p =.01). Conclusion: Our findings suggest that, in a high-income country such as Denmark, groups of adolescents growing up in homes with mold and moisture during mid-childhood might be at increased risk of current asthma at age 18. Adolescents who grew-up in a farmhouse and who were exposed to pets seem less likely to suffer from asthma by age 18.
AB - Background: Many residential indoor environments may have an impact on children’s respiratory health. Objectives: The aims of this study were to identify latent classes of children from the Danish National Birth Cohort (DNBC) who share similar patterns of exposure to indoor home characteristics, and to examine the association between membership in the latent classes and asthma in adolescence. Methods: We included data on residential indoor characteristics of offspring from the DNBC whose mothers had responded to the child’s 11-year follow-up and who had data on asthma from the 18-year follow-up. Number of classes and associations were estimated using latent class analysis. To account for sample selection, we applied inverse probability weighting. Results: Our final model included five latent classes. The probability of current asthma at 18 years was highest among individuals in class one with higher clustering on household dampness (9, 95%CI 0.06–0.13). Individuals in class four (with higher clustering on pets ownership and living in a farm) had a lower risk of current asthma at age 18 compared to individuals in class one (with higher clustering on household dampness) (OR 0.53 (95%CI 0.32–0.88), p =.01). Conclusion: Our findings suggest that, in a high-income country such as Denmark, groups of adolescents growing up in homes with mold and moisture during mid-childhood might be at increased risk of current asthma at age 18. Adolescents who grew-up in a farmhouse and who were exposed to pets seem less likely to suffer from asthma by age 18.
KW - Asthma
KW - Danish National Birth Cohort
KW - Environmental epidemiology
KW - Home characteristics
KW - Indoor air pollution
U2 - 10.1007/s10654-023-01051-y
DO - 10.1007/s10654-023-01051-y
M3 - Journal article
C2 - 37865616
AN - SCOPUS:85174607943
VL - 39
SP - 51
EP - 65
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
ER -