Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin

Gwladys I Bertin; Thomas Lavstsen; François Guillonneau; Justin Doritchamou; Christian W Wang; Jakob S Jespersen; Sem Ezimegnon; Nadine Fievet; Maroufou J Alao; Francis Lalya; Achille Massougbodji; Nicaise Tuikue Ndam; Thor G Theander; Philippe Deloron

doi:10.1371/journal.pone.0068368

Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin

Gwladys I Bertin, Thomas Lavstsen, François Guillonneau, Justin Doritchamou, Christian W Wang, Jakob S Jespersen, Sem Ezimegnon, Nadine Fievet, Maroufou J Alao, Francis Lalya, Achille Massougbodji, Nicaise Tuikue Ndam, Thor G Theander, Philippe Deloron

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ("domain cassettes" (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.

Original language	English
Journal	P L o S One
Volume	8
Issue number	7
Pages (from-to)	e68368
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0068368
Publication status	Published - 2013

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10.1371/journal.pone.0068368

Cite this

Bertin, G. I., Lavstsen, T., Guillonneau, F., Doritchamou, J., Wang, C. W., Jespersen, J. S., Ezimegnon, S., Fievet, N., Alao, M. J., Lalya, F., Massougbodji, A., Ndam, N. T., Theander, T. G., & Deloron, P. (2013). Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin. P L o S One, 8(7), e68368. https://doi.org/10.1371/journal.pone.0068368

Bertin, GI, Lavstsen, T, Guillonneau, F, Doritchamou, J, Wang, CW , Jespersen, JS, Ezimegnon, S, Fievet, N, Alao, MJ, Lalya, F, Massougbodji, A, Ndam, NT, Theander, TG & Deloron, P 2013, 'Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin', P L o S One, vol. 8, no. 7, pp. e68368. https://doi.org/10.1371/journal.pone.0068368

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abstract = "Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ({"}domain cassettes{"} (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.",

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AU - Bertin, Gwladys I

AU - Lavstsen, Thomas

AU - Guillonneau, François

AU - Doritchamou, Justin

AU - Wang, Christian W

AU - Jespersen, Jakob S

AU - Ezimegnon, Sem

AU - Fievet, Nadine

AU - Alao, Maroufou J

AU - Lalya, Francis

AU - Massougbodji, Achille

AU - Ndam, Nicaise Tuikue

AU - Theander, Thor G

AU - Deloron, Philippe

PY - 2013

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AB - Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology PfEMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains ("domain cassettes" (DC)). The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.

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DO - 10.1371/journal.pone.0068368

M3 - Journal article

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