Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho

Helene Narvestad-Bøttger; Anne Winther-Larsen; Jens Haugbølle Bjerre; Morten Hanefeld Dziegiel; Anne Todsen Hansen; Henrik Hasle

doi:10.1097/MPH.0000000000002790

Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho

Helene Narvestad-Bøttger^*, Anne Winther-Larsen, Jens Haugbølle Bjerre, Morten Hanefeld Dziegiel, Anne Todsen Hansen, Henrik Hasle

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×10⁹/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.

Original language	English
Journal	Journal of Pediatric Hematology/Oncology
Volume	46
Issue number	1
Pages (from-to)	E111-E114
Number of pages	4
ISSN	1077-4114
DOIs	https://doi.org/10.1097/MPH.0000000000002790
Publication status	Published - 2024

Bibliographical note

Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.

Keywords

Hb Mizuho
hemoglobinopathy
reticulocytosis
splenectomy

Access to Document

10.1097/MPH.0000000000002790

Cite this

Extreme Reticulocytosis after Splenectomy in a Patient with Hemoglobin Mizuho. / Narvestad-Bøttger, Helene; Winther-Larsen, Anne; Haugbølle Bjerre, Jens; Dziegiel, Morten Hanefeld; Hansen, Anne Todsen; Hasle, Henrik.

In: Journal of Pediatric Hematology/Oncology, Vol. 46, No. 1, 2024, p. E111-E114.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×109/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.",

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AU - Narvestad-Bøttger, Helene

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AU - Dziegiel, Morten Hanefeld

AU - Hansen, Anne Todsen

AU - Hasle, Henrik

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AB - Background: Patients with Hb Mizuho may be splenectomized at a young age to decrease their need for blood transfusions. Observations: Transfusion-dependency decreased dramatically in a 4-year-old white boy with Hb Mizuho after splenectomy. Surprisingly, he developed reticulocytosis (>1000×109/L) with a peak reticulocyte percentage of 49%, and erythrocyte abnormalities, including Heinz bodies, Howell-Jolly bodies, and basophilic stippling. Manual reticulocyte counting and flow cytometric measurement with anti-CD71 antibodies supported a truly elevated reticulocyte count. Conclusions: We propose possible explanations for the extreme reticulocytosis that arose postsplenectomy and compare the reticulocyte count in the present case with previously published cases.

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