False-positive Human Papillomavirus DNA tests in cervical screening: it is all in a definition

Matejka Rebolj; Igor Pribac; Elsebeth Lynge

doi:10.1016/j.ejca.2010.08.010

False-positive Human Papillomavirus DNA tests in cervical screening: it is all in a definition

Matejka Rebolj, Igor Pribac, Elsebeth Lynge

Center of Epidemiology and Screening

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

Based on data from randomised controlled trials (RCT) on primary cervical screening, it has been reported that the problem of more frequent false-positive tests in Human Papillomavirus (HPV) DNA screening compared to cytology could be overcome. However, these reports predominantly operated with a narrow definition of a (false-)positive test. The aim of this paper was to illustrate how the narrow definition affected the measured adverse effects of HPV DNA screening compared with cytology screening.

Original language	English
Journal	European Journal of Cancer
Volume	47
Issue number	2
Pages (from-to)	255-261
Number of pages	7
ISSN	0959-8049
DOIs	https://doi.org/10.1016/j.ejca.2010.08.010
Publication status	Published - Jan 2011

Keywords

Adult
Cervical Intraepithelial Neoplasia
DNA, Viral
Early Detection of Cancer
False Positive Reactions
Female
Humans
Middle Aged
Papillomaviridae
Papillomavirus Infections
Randomized Controlled Trials as Topic
Sensitivity and Specificity
Uterine Cervical Neoplasms
Vaginal Smears

Access to Document

10.1016/j.ejca.2010.08.010

Cite this

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title = "False-positive Human Papillomavirus DNA tests in cervical screening: it is all in a definition",

abstract = "Based on data from randomised controlled trials (RCT) on primary cervical screening, it has been reported that the problem of more frequent false-positive tests in Human Papillomavirus (HPV) DNA screening compared to cytology could be overcome. However, these reports predominantly operated with a narrow definition of a (false-)positive test. The aim of this paper was to illustrate how the narrow definition affected the measured adverse effects of HPV DNA screening compared with cytology screening.",

keywords = "Adult, Cervical Intraepithelial Neoplasia, DNA, Viral, Early Detection of Cancer, False Positive Reactions, Female, Humans, Middle Aged, Papillomaviridae, Papillomavirus Infections, Randomized Controlled Trials as Topic, Sensitivity and Specificity, Uterine Cervical Neoplasms, Vaginal Smears",

author = "Matejka Rebolj and Igor Pribac and Elsebeth Lynge",

year = "2011",

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T2 - it is all in a definition

AU - Rebolj, Matejka

AU - Pribac, Igor

AU - Lynge, Elsebeth

PY - 2011/1

Y1 - 2011/1

N2 - Based on data from randomised controlled trials (RCT) on primary cervical screening, it has been reported that the problem of more frequent false-positive tests in Human Papillomavirus (HPV) DNA screening compared to cytology could be overcome. However, these reports predominantly operated with a narrow definition of a (false-)positive test. The aim of this paper was to illustrate how the narrow definition affected the measured adverse effects of HPV DNA screening compared with cytology screening.

AB - Based on data from randomised controlled trials (RCT) on primary cervical screening, it has been reported that the problem of more frequent false-positive tests in Human Papillomavirus (HPV) DNA screening compared to cytology could be overcome. However, these reports predominantly operated with a narrow definition of a (false-)positive test. The aim of this paper was to illustrate how the narrow definition affected the measured adverse effects of HPV DNA screening compared with cytology screening.

KW - Adult

KW - Cervical Intraepithelial Neoplasia

KW - DNA, Viral

KW - Early Detection of Cancer

KW - False Positive Reactions

KW - Female

KW - Humans

KW - Middle Aged

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Randomized Controlled Trials as Topic

KW - Sensitivity and Specificity

KW - Uterine Cervical Neoplasms

KW - Vaginal Smears

U2 - 10.1016/j.ejca.2010.08.010

DO - 10.1016/j.ejca.2010.08.010

M3 - Journal article

C2 - 20833033

VL - 47

SP - 255

EP - 261

JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

SN - 0959-8049

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