FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Susanna Søberg; Camilla Helene Sandholt; Naja  Z. Jespersen; Ulla Toft; Anja  L. Madsen; Stephanie Ø von Holstein-Rathlou; Trisha Jean Grevengoed; Karl Bang Christensen; Wender Bredie; Matthew J Potthoff; Thomas P. J. Solomon; Camilla Charlotte Schéele; Allan René Linneberg; Torben Jørgensen; Oluf Borbye Pedersen; Torben Hansen; Matthew Paul Gillum; Niels Grarup

doi:10.1016/j.cmet.2017.04.009

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Susanna Søberg, Camilla Helene Sandholt, Naja Z. Jespersen, Ulla Toft, Anja L. Madsen, Stephanie Ø von Holstein-Rathlou, Trisha Jean Grevengoed, Karl Bang Christensen, Wender Bredie, Matthew J Potthoff, Thomas P. J. Solomon, Camilla Charlotte Schéele, Allan René Linneberg, Torben Jørgensen, Oluf Borbye Pedersen, Torben Hansen, Matthew Paul Gillum, Niels Grarup

Research output: Contribution to journal › Journal article › Research › peer-review

155 Citations (Scopus)

Abstract

The liking and selective ingestion of palatable
foods—including sweets—is biologically controlled,
and dysfunction of this regulation may promote unhealthy
eating, obesity, and disease. The hepatokine
fibroblast growth factor 21 (FGF21) reduces sweet
consumption in rodents and primates, whereas
knockout of Fgf21 increases sugar consumption in
mice. To investigate the relevance of these findings
in humans, we genotyped variants in the FGF21 locus
in participants from the Danish Inter99 cohort
(n = 6,514) and examined their relationship with a
detailed range of food and ingestive behaviors. This
revealed statistically significant associations between
FGF21 rs838133 and increased consumption
of candy, as well as nominal associations with
increased alcohol intake and daily smoking. Moreover,
in a separate clinical study, plasma FGF21
levels increased acutely after oral sucrose ingestion
and were elevated in fasted sweet-disliking individuals.
These data suggest the liver may secrete
hormones that influence eating behavior.

Original language	English
Journal	Cell Metabolism
Volume	25
Issue number	5
Pages (from-to)	1045-1053
Number of pages	9
ISSN	1550-4131
DOIs	https://doi.org/10.1016/j.cmet.2017.04.009
Publication status	Published - 2017

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10.1016/j.cmet.2017.04.009

Cite this

Søberg, S., Sandholt, C. H., Z. Jespersen, N., Toft, U., L. Madsen, A., von Holstein-Rathlou, S. Ø., Grevengoed, T. J., Christensen, K. B., Bredie, W., Potthoff, M. J., P. J. Solomon, T., Schéele, C. C., Linneberg, A. R., Jørgensen, T., Pedersen, O. B., Hansen, T., Gillum, M. P., & Grarup, N. (2017). FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. Cell Metabolism, 25(5), 1045-1053. https://doi.org/10.1016/j.cmet.2017.04.009

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. / Søberg, Susanna; Sandholt, Camilla Helene; Z. Jespersen, Naja ; Toft, Ulla; L. Madsen, Anja ; von Holstein-Rathlou, Stephanie Ø ; Grevengoed, Trisha Jean ; Christensen, Karl Bang ; Bredie, Wender; Potthoff, Matthew J; P. J. Solomon, Thomas; Schéele, Camilla Charlotte ; Linneberg, Allan René; Jørgensen, Torben; Pedersen, Oluf Borbye ; Hansen, Torben; Gillum, Matthew Paul; Grarup, Niels.

In: Cell Metabolism, Vol. 25, No. 5, 2017, p. 1045-1053.

Research output: Contribution to journal › Journal article › Research › peer-review

Søberg, S, Sandholt, CH, Z. Jespersen, N, Toft, U, L. Madsen, A, von Holstein-Rathlou, SØ , Grevengoed, TJ , Christensen, KB , Bredie, W, Potthoff, MJ, P. J. Solomon, T, Schéele, CC , Linneberg, AR, Jørgensen, T, Pedersen, OB , Hansen, T, Gillum, MP & Grarup, N 2017, 'FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans', Cell Metabolism, vol. 25, no. 5, pp. 1045-1053. https://doi.org/10.1016/j.cmet.2017.04.009

Søberg, Susanna ; Sandholt, Camilla Helene ; Z. Jespersen, Naja ; Toft, Ulla ; L. Madsen, Anja ; von Holstein-Rathlou, Stephanie Ø ; Grevengoed, Trisha Jean ; Christensen, Karl Bang ; Bredie, Wender ; Potthoff, Matthew J ; P. J. Solomon, Thomas ; Schéele, Camilla Charlotte ; Linneberg, Allan René ; Jørgensen, Torben ; Pedersen, Oluf Borbye ; Hansen, Torben ; Gillum, Matthew Paul ; Grarup, Niels. / FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans. In: Cell Metabolism. 2017 ; Vol. 25, No. 5. pp. 1045-1053.

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abstract = "The liking and selective ingestion of palatablefoods—including sweets—is biologically controlled,and dysfunction of this regulation may promote unhealthyeating, obesity, and disease. The hepatokinefibroblast growth factor 21 (FGF21) reduces sweetconsumption in rodents and primates, whereasknockout of Fgf21 increases sugar consumption inmice. To investigate the relevance of these findingsin humans, we genotyped variants in the FGF21 locusin participants from the Danish Inter99 cohort(n = 6,514) and examined their relationship with adetailed range of food and ingestive behaviors. Thisrevealed statistically significant associations betweenFGF21 rs838133 and increased consumptionof candy, as well as nominal associations withincreased alcohol intake and daily smoking. Moreover,in a separate clinical study, plasma FGF21levels increased acutely after oral sucrose ingestionand were elevated in fasted sweet-disliking individuals.These data suggest the liver may secretehormones that influence eating behavior.",

author = "Susanna S{\o}berg and Sandholt, {Camilla Helene} and {Z. Jespersen}, Naja and Ulla Toft and {L. Madsen}, Anja and {von Holstein-Rathlou}, {Stephanie {\O}} and Grevengoed, {Trisha Jean} and Christensen, {Karl Bang} and Wender Bredie and Potthoff, {Matthew J} and {P. J. Solomon}, Thomas and Sch{\'e}ele, {Camilla Charlotte} and Linneberg, {Allan Ren{\'e}} and Torben J{\o}rgensen and Pedersen, {Oluf Borbye} and Torben Hansen and Gillum, {Matthew Paul} and Niels Grarup",

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AU - Søberg, Susanna

AU - Sandholt, Camilla Helene

AU - Z. Jespersen, Naja

AU - Toft, Ulla

AU - L. Madsen, Anja

AU - von Holstein-Rathlou, Stephanie Ø

AU - Grevengoed, Trisha Jean

AU - Christensen, Karl Bang

AU - Bredie, Wender

AU - Potthoff, Matthew J

AU - P. J. Solomon, Thomas

AU - Schéele, Camilla Charlotte

AU - Linneberg, Allan René

AU - Jørgensen, Torben

AU - Pedersen, Oluf Borbye

AU - Hansen, Torben

AU - Gillum, Matthew Paul

AU - Grarup, Niels

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N2 - The liking and selective ingestion of palatablefoods—including sweets—is biologically controlled,and dysfunction of this regulation may promote unhealthyeating, obesity, and disease. The hepatokinefibroblast growth factor 21 (FGF21) reduces sweetconsumption in rodents and primates, whereasknockout of Fgf21 increases sugar consumption inmice. To investigate the relevance of these findingsin humans, we genotyped variants in the FGF21 locusin participants from the Danish Inter99 cohort(n = 6,514) and examined their relationship with adetailed range of food and ingestive behaviors. Thisrevealed statistically significant associations betweenFGF21 rs838133 and increased consumptionof candy, as well as nominal associations withincreased alcohol intake and daily smoking. Moreover,in a separate clinical study, plasma FGF21levels increased acutely after oral sucrose ingestionand were elevated in fasted sweet-disliking individuals.These data suggest the liver may secretehormones that influence eating behavior.

AB - The liking and selective ingestion of palatablefoods—including sweets—is biologically controlled,and dysfunction of this regulation may promote unhealthyeating, obesity, and disease. The hepatokinefibroblast growth factor 21 (FGF21) reduces sweetconsumption in rodents and primates, whereasknockout of Fgf21 increases sugar consumption inmice. To investigate the relevance of these findingsin humans, we genotyped variants in the FGF21 locusin participants from the Danish Inter99 cohort(n = 6,514) and examined their relationship with adetailed range of food and ingestive behaviors. Thisrevealed statistically significant associations betweenFGF21 rs838133 and increased consumptionof candy, as well as nominal associations withincreased alcohol intake and daily smoking. Moreover,in a separate clinical study, plasma FGF21levels increased acutely after oral sucrose ingestionand were elevated in fasted sweet-disliking individuals.These data suggest the liver may secretehormones that influence eating behavior.

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DO - 10.1016/j.cmet.2017.04.009

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JO - Cell Metabolism

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