Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial

Laerke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo Chawes; Rebecca K Vinding; Anna-Rosa C Mora-Jensen; Jonathan Thorsen; Sarah Nørgaard; Bjørn H Ebdrup; Jens R M Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard

doi:10.1111/cdev.13541

Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial

Laerke Sass, Elín Bjarnadóttir, Jakob Stokholm, Bo Chawes, Rebecca K Vinding, Anna-Rosa C Mora-Jensen, Jonathan Thorsen, Sarah Nørgaard, Bjørn H Ebdrup, Jens R M Jepsen, Birgitte Fagerlund, Klaus Bønnelykke, Lotte Lauritzen, Hans Bisgaard^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

9 Citations (Scopus)

Abstract

A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC₂₀₁₀ mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

Original language	English
Journal	Child Development
Volume	92
Issue number	4
Pages (from-to)	1624-1635
Number of pages	12
ISSN	0009-3920
DOIs	https://doi.org/10.1111/cdev.13541
Publication status	Published - 2021

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10.1111/cdev.13541

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Sass, L., Bjarnadóttir, E., Stokholm, J., Chawes, B., Vinding, R. K., Mora-Jensen, A-R. C., Thorsen, J., Nørgaard, S., Ebdrup, B. H., Jepsen, J. R. M., Fagerlund, B., Bønnelykke, K., Lauritzen, L., & Bisgaard, H. (2021). Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial. Child Development, 92(4), 1624-1635. https://doi.org/10.1111/cdev.13541

Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial. / Sass, Laerke; Bjarnadóttir, Elín ; Stokholm, Jakob ; Chawes, Bo; Vinding, Rebecca K; Mora-Jensen, Anna-Rosa C; Thorsen, Jonathan; Nørgaard, Sarah; Ebdrup, Bjørn H; Jepsen, Jens R M; Fagerlund, Birgitte ; Bønnelykke, Klaus ; Lauritzen, Lotte; Bisgaard, Hans.

In: Child Development, Vol. 92, No. 4, 2021, p. 1624-1635.

Research output: Contribution to journal › Journal article › Research › peer-review

Sass, L, Bjarnadóttir, E , Stokholm, J , Chawes, B, Vinding, RK, Mora-Jensen, A-RC, Thorsen, J, Nørgaard, S, Ebdrup, BH, Jepsen, JRM, Fagerlund, B , Bønnelykke, K , Lauritzen, L & Bisgaard, H 2021, 'Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial', Child Development, vol. 92, no. 4, pp. 1624-1635. https://doi.org/10.1111/cdev.13541

Sass, Laerke ; Bjarnadóttir, Elín ; Stokholm, Jakob ; Chawes, Bo ; Vinding, Rebecca K ; Mora-Jensen, Anna-Rosa C ; Thorsen, Jonathan ; Nørgaard, Sarah ; Ebdrup, Bjørn H ; Jepsen, Jens R M ; Fagerlund, Birgitte ; Bønnelykke, Klaus ; Lauritzen, Lotte ; Bisgaard, Hans. / Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial. In: Child Development. 2021 ; Vol. 92, No. 4. pp. 1624-1635.

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abstract = "A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.",

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AU - Vinding, Rebecca K

AU - Mora-Jensen, Anna-Rosa C

AU - Thorsen, Jonathan

AU - Nørgaard, Sarah

AU - Ebdrup, Bjørn H

AU - Jepsen, Jens R M

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