TY - JOUR
T1 - Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation
T2 - The CCC2000 Eye Study
AU - Hansen, Mathias Hvidtfelt
AU - Li, Xiao Qiang
AU - Larsen, Michael
AU - Olsen, Else Marie
AU - Skovgaard, Anne Mette
AU - Kessel, Line
AU - Munch, Inger Christine
PY - 2019
Y1 - 2019
N2 - PURPOSE. We describe changes in choroidal thickness from age 11 to 16 years and its
association with ocular biometrics and body development.
METHOD. In this longitudinal, population-based observational study, choroidal thickness was
measured subfoveally and 1- and 3-mm temporal thereof using enhanced depth imaging
spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted
for age and the time of day that the scan was performed.
RESULTS. The study included 687 participants (304 boys). Median (interquartile range [IQR])
age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in
choroidal thickness was 33, 27, and 11 lm at the three respective locations. The subfoveal
choroid thickened less in eyes whose axial length increased more (boys, b ¼ 85 lm/mm;
95% confidence interval [CI], 104 to 66, P < 0.0001; girls, b ¼ 105 lm/mm; 95% CI,
121 to 89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11
lm/diopters [D]; 95% CI, 4.0 to 18, P ¼ 0.0022; girls, 22 lm/D; 95% CI, 16 to 27, P < 0.0001).
Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner
stage 4 vs. 1; 39 lm’ 95% CI, 72 to 5.9, P ¼ 0.021) and who had a longer baseline axial
length (b ¼ 8.6 lm/mm; 95% CI, 15 to 2.7, P ¼ 0.0043), and more in girls who grew
taller (b ¼ 0.9 lm/cm; 95% CI, 0.1 to 1.7, P ¼ 0.026).
CONCLUSIONS. The choroid increased in thickness from age 11 to 16 years. The increase was
greater in girls with later sexual maturation and smaller in eyes that added more axial length
and had a relatively negative refractive development.
Keywords: choroidal thickness changes, longitudinal study, cohort study, axial eye growth
AB - PURPOSE. We describe changes in choroidal thickness from age 11 to 16 years and its
association with ocular biometrics and body development.
METHOD. In this longitudinal, population-based observational study, choroidal thickness was
measured subfoveally and 1- and 3-mm temporal thereof using enhanced depth imaging
spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted
for age and the time of day that the scan was performed.
RESULTS. The study included 687 participants (304 boys). Median (interquartile range [IQR])
age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in
choroidal thickness was 33, 27, and 11 lm at the three respective locations. The subfoveal
choroid thickened less in eyes whose axial length increased more (boys, b ¼ 85 lm/mm;
95% confidence interval [CI], 104 to 66, P < 0.0001; girls, b ¼ 105 lm/mm; 95% CI,
121 to 89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11
lm/diopters [D]; 95% CI, 4.0 to 18, P ¼ 0.0022; girls, 22 lm/D; 95% CI, 16 to 27, P < 0.0001).
Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner
stage 4 vs. 1; 39 lm’ 95% CI, 72 to 5.9, P ¼ 0.021) and who had a longer baseline axial
length (b ¼ 8.6 lm/mm; 95% CI, 15 to 2.7, P ¼ 0.0043), and more in girls who grew
taller (b ¼ 0.9 lm/cm; 95% CI, 0.1 to 1.7, P ¼ 0.026).
CONCLUSIONS. The choroid increased in thickness from age 11 to 16 years. The increase was
greater in girls with later sexual maturation and smaller in eyes that added more axial length
and had a relatively negative refractive development.
Keywords: choroidal thickness changes, longitudinal study, cohort study, axial eye growth
KW - choroidal thickness changes
KW - longitudinal study
KW - cohort study
KW - axial eye growth
U2 - 10.1167/iovs.19-26807
DO - 10.1167/iovs.19-26807
M3 - Journal article
C2 - 31546258
VL - 60
SP - 3930
EP - 3936
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
SN - 0146-0404
IS - 12
ER -