Forssman and the staphylococcal hemolysins

Hanne Ingmer*, Jørgen J. Leisner, Stephanie Fulaz

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Forssman was a Swedish pathologist and microbiologist who, in the 1920s and 1930s conducted a long series of experiments that led to unique insights into surface antigens of blood cells, as well as added to the discrimination of toxins produced by staphylococci that lyse red blood cells. This review takes offset in the studies published by Forssman in APMIS addressing the hemolytic properties of staphylococcal toxins displayed against erythrocytes of animal and human origin. In light of current knowledge, we will discuss the insights we now have and how they may pave the way for curing infections with pathogenic staphylococci, including Staphylococcus aureus.

Original languageEnglish
JournalAPMIS
ISSN0903-4641
DOIs
Publication statusE-pub ahead of print - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.

Keywords

  • hemolysin
  • quorum sensing vaccine
  • regulation
  • Toxin

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