Free-living energy expenditure reduced after deep brain stimulation surgery for Parkinson's disease

Hans Ulrik Jørgensen; Lene Werdelin; Annemette Lokkegaard; Klaas R Westerterp; Lene Simonsen

doi:10.1111/j.1475-097X.2011.01079.x

Free-living energy expenditure reduced after deep brain stimulation surgery for Parkinson's disease

Hans Ulrik Jørgensen, Lene Werdelin, Annemette Lokkegaard, Klaas R Westerterp, Lene Simonsen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The clinical picture in Parkinson's disease (PD) is characterized by bradykinesia, rigidity, resting tremor and postural instability. In advanced stages of the disease, many patients will experience reduced efficacy of medication with fluctuations in symptoms and dyskinesias. Surgical treatment with deep brain stimulation in the subthalamic nucleus (STN-DBS) is now considered the gold standard in fluctuating PD. Many patients experience a gain of weight following the surgery. The aim of this study was to identify possible mechanisms, which may contribute to body weight gain in patients with PD following bilateral STN-DBS surgery.

Original language	English
Journal	Clinical Physiology and Functional Imaging
Volume	32
Issue number	3
Pages (from-to)	214-20
Number of pages	7
ISSN	1475-0961
DOIs	https://doi.org/10.1111/j.1475-097X.2011.01079.x
Publication status	Published - 2012

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10.1111/j.1475-097X.2011.01079.x

Cite this

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title = "Free-living energy expenditure reduced after deep brain stimulation surgery for Parkinson's disease",

abstract = "The clinical picture in Parkinson's disease (PD) is characterized by bradykinesia, rigidity, resting tremor and postural instability. In advanced stages of the disease, many patients will experience reduced efficacy of medication with fluctuations in symptoms and dyskinesias. Surgical treatment with deep brain stimulation in the subthalamic nucleus (STN-DBS) is now considered the gold standard in fluctuating PD. Many patients experience a gain of weight following the surgery. The aim of this study was to identify possible mechanisms, which may contribute to body weight gain in patients with PD following bilateral STN-DBS surgery.",

author = "J{\o}rgensen, {Hans Ulrik} and Lene Werdelin and Annemette Lokkegaard and Westerterp, {Klaas R} and Lene Simonsen",

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T1 - Free-living energy expenditure reduced after deep brain stimulation surgery for Parkinson's disease

AU - Jørgensen, Hans Ulrik

AU - Werdelin, Lene

AU - Lokkegaard, Annemette

AU - Westerterp, Klaas R

AU - Simonsen, Lene

PY - 2012

Y1 - 2012

N2 - The clinical picture in Parkinson's disease (PD) is characterized by bradykinesia, rigidity, resting tremor and postural instability. In advanced stages of the disease, many patients will experience reduced efficacy of medication with fluctuations in symptoms and dyskinesias. Surgical treatment with deep brain stimulation in the subthalamic nucleus (STN-DBS) is now considered the gold standard in fluctuating PD. Many patients experience a gain of weight following the surgery. The aim of this study was to identify possible mechanisms, which may contribute to body weight gain in patients with PD following bilateral STN-DBS surgery.

AB - The clinical picture in Parkinson's disease (PD) is characterized by bradykinesia, rigidity, resting tremor and postural instability. In advanced stages of the disease, many patients will experience reduced efficacy of medication with fluctuations in symptoms and dyskinesias. Surgical treatment with deep brain stimulation in the subthalamic nucleus (STN-DBS) is now considered the gold standard in fluctuating PD. Many patients experience a gain of weight following the surgery. The aim of this study was to identify possible mechanisms, which may contribute to body weight gain in patients with PD following bilateral STN-DBS surgery.

U2 - 10.1111/j.1475-097X.2011.01079.x

DO - 10.1111/j.1475-097X.2011.01079.x

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