Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Yaoting Gui; Guangwu Guo; Yi Huang; Xueda Hu; Aifa Tang; Shengjie Gao; Renhua Wu; Chao Chen; Xianxin Li; Liang Zhou; Minghui He; Zesong Li; Xiaojuan Sun; Wenlong Jia; Jinnong Chen; Shangming Yang; Fangjian Zhou; Xiaokun Zhao; Shengqing Wan; Rui Ye; Chaozhao Liang; chunxiao  Liu; Peide Huang; Chunxiao Liu; Hui Jiang; Yong Wang; Hancheng Zheng; Liang Sun; Xingwang Liu; Zhimao Jiang; Dafei Feng; Xi Jing Chen; Song Wu; Jing Zou; Zhongfu Zhang; Ruilin Yang; Jun Zhao; Congjie Xu; Weihua Yin; Zhichen Guan; Jiongxian Ye; Hong Zhang; Jingxiang Li; Karsten Kristiansen; Michael L Nickerson; Dan Theodorescu; Yingrui Li; Xiuqing Zhang; Songgang Li; Jian Wang; Huanming Yang; Jun Wang; Zhiming Cai

doi:10.1038/ng.907

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Yaoting Gui, Guangwu Guo, Yi Huang, Xueda Hu, Aifa Tang, Shengjie Gao, Renhua Wu, Chao Chen, Xianxin Li, Liang Zhou, Minghui He, Zesong Li, Xiaojuan Sun, Wenlong Jia, Jinnong Chen, Shangming Yang, Fangjian Zhou, Xiaokun Zhao, Shengqing Wan, Rui YeChaozhao Liang, chunxiao Liu, Peide Huang, Chunxiao Liu, Hui Jiang, Yong Wang, Hancheng Zheng, Liang Sun, Xingwang Liu, Zhimao Jiang, Dafei Feng, Xi Jing Chen, Song Wu, Jing Zou, Zhongfu Zhang, Ruilin Yang, Jun Zhao, Congjie Xu, Weihua Yin, Zhichen Guan, Jiongxian Ye, Hong Zhang, Jingxiang Li, Karsten Kristiansen, Michael L Nickerson, Dan Theodorescu, Yingrui Li, Xiuqing Zhang, Songgang Li, Jian Wang, Huanming Yang, Jun Wang, Zhiming Cai

Department of Biology

Research output: Contribution to journal › Letter › Research › peer-review

618 Citations (Scopus)

Abstract

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.

Original language	English
Journal	Nature Genetics
Volume	43
Issue number	9
Pages (from-to)	875-8
Number of pages	4
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.907
Publication status	Published - 2011

Keywords

Carcinoma, Transitional Cell
Chromatin Assembly and Disassembly
Chromosome Aberrations
Gene Expression Regulation, Neoplastic
Humans
Mutation
Urinary Bladder Neoplasms

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10.1038/ng.907

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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. / Gui, Yaoting; Guo, Guangwu; Huang, Yi; Hu, Xueda; Tang, Aifa; Gao, Shengjie; Wu, Renhua; Chen, Chao; Li, Xianxin; Zhou, Liang; He, Minghui; Li, Zesong; Sun, Xiaojuan; Jia, Wenlong; Chen, Jinnong; Yang, Shangming; Zhou, Fangjian; Zhao, Xiaokun; Wan, Shengqing; Ye, Rui; Liang, Chaozhao; Liu, chunxiao ; Huang, Peide; Liu, Chunxiao; Jiang, Hui; Wang, Yong; Zheng, Hancheng; Sun, Liang; Liu, Xingwang; Jiang, Zhimao; Feng, Dafei; Chen, Xi Jing; Wu, Song; Zou, Jing; Zhang, Zhongfu; Yang, Ruilin; Zhao, Jun; Xu, Congjie; Yin, Weihua; Guan, Zhichen; Ye, Jiongxian; Zhang, Hong; Li, Jingxiang; Kristiansen, Karsten; Nickerson, Michael L; Theodorescu, Dan; Li, Yingrui; Zhang, Xiuqing; Li, Songgang; Wang, Jian; Yang, Huanming; Wang, Jun; Cai, Zhiming.

In: Nature Genetics, Vol. 43, No. 9, 2011, p. 875-8.

Research output: Contribution to journal › Letter › Research › peer-review

Gui, Y, Guo, G, Huang, Y, Hu, X, Tang, A, Gao, S, Wu, R, Chen, C, Li, X, Zhou, L, He, M, Li, Z, Sun, X, Jia, W, Chen, J, Yang, S, Zhou, F, Zhao, X, Wan, S, Ye, R, Liang, C, Liu, C, Huang, P, Liu, C, Jiang, H, Wang, Y, Zheng, H, Sun, L, Liu, X, Jiang, Z, Feng, D, Chen, XJ, Wu, S, Zou, J, Zhang, Z, Yang, R, Zhao, J, Xu, C, Yin, W, Guan, Z, Ye, J, Zhang, H, Li, J, Kristiansen, K, Nickerson, ML, Theodorescu, D, Li, Y, Zhang, X, Li, S, Wang, J, Yang, H, Wang, J & Cai, Z 2011, 'Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder', Nature Genetics, vol. 43, no. 9, pp. 875-8. https://doi.org/10.1038/ng.907

Gui, Yaoting ; Guo, Guangwu ; Huang, Yi ; Hu, Xueda ; Tang, Aifa ; Gao, Shengjie ; Wu, Renhua ; Chen, Chao ; Li, Xianxin ; Zhou, Liang ; He, Minghui ; Li, Zesong ; Sun, Xiaojuan ; Jia, Wenlong ; Chen, Jinnong ; Yang, Shangming ; Zhou, Fangjian ; Zhao, Xiaokun ; Wan, Shengqing ; Ye, Rui ; Liang, Chaozhao ; Liu, chunxiao ; Huang, Peide ; Liu, Chunxiao ; Jiang, Hui ; Wang, Yong ; Zheng, Hancheng ; Sun, Liang ; Liu, Xingwang ; Jiang, Zhimao ; Feng, Dafei ; Chen, Xi Jing ; Wu, Song ; Zou, Jing ; Zhang, Zhongfu ; Yang, Ruilin ; Zhao, Jun ; Xu, Congjie ; Yin, Weihua ; Guan, Zhichen ; Ye, Jiongxian ; Zhang, Hong ; Li, Jingxiang ; Kristiansen, Karsten ; Nickerson, Michael L ; Theodorescu, Dan ; Li, Yingrui ; Zhang, Xiuqing ; Li, Songgang ; Wang, Jian ; Yang, Huanming ; Wang, Jun ; Cai, Zhiming. / Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. In: Nature Genetics. 2011 ; Vol. 43, No. 9. pp. 875-8.

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title = "Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder",

abstract = "Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.",

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author = "Yaoting Gui and Guangwu Guo and Yi Huang and Xueda Hu and Aifa Tang and Shengjie Gao and Renhua Wu and Chao Chen and Xianxin Li and Liang Zhou and Minghui He and Zesong Li and Xiaojuan Sun and Wenlong Jia and Jinnong Chen and Shangming Yang and Fangjian Zhou and Xiaokun Zhao and Shengqing Wan and Rui Ye and Chaozhao Liang and chunxiao Liu and Peide Huang and Chunxiao Liu and Hui Jiang and Yong Wang and Hancheng Zheng and Liang Sun and Xingwang Liu and Zhimao Jiang and Dafei Feng and Chen, {Xi Jing} and Song Wu and Jing Zou and Zhongfu Zhang and Ruilin Yang and Jun Zhao and Congjie Xu and Weihua Yin and Zhichen Guan and Jiongxian Ye and Hong Zhang and Jingxiang Li and Karsten Kristiansen and Nickerson, {Michael L} and Dan Theodorescu and Yingrui Li and Xiuqing Zhang and Songgang Li and Jian Wang and Huanming Yang and Jun Wang and Zhiming Cai",

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T1 - Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

AU - Gui, Yaoting

AU - Guo, Guangwu

AU - Huang, Yi

AU - Hu, Xueda

AU - Tang, Aifa

AU - Gao, Shengjie

AU - Wu, Renhua

AU - Chen, Chao

AU - Li, Xianxin

AU - Zhou, Liang

AU - He, Minghui

AU - Li, Zesong

AU - Sun, Xiaojuan

AU - Jia, Wenlong

AU - Chen, Jinnong

AU - Yang, Shangming

AU - Zhou, Fangjian

AU - Zhao, Xiaokun

AU - Wan, Shengqing

AU - Ye, Rui

AU - Liang, Chaozhao

AU - Liu, chunxiao

AU - Huang, Peide

AU - Liu, Chunxiao

AU - Jiang, Hui

AU - Wang, Yong

AU - Zheng, Hancheng

AU - Sun, Liang

AU - Liu, Xingwang

AU - Jiang, Zhimao

AU - Feng, Dafei

AU - Chen, Xi Jing

AU - Wu, Song

AU - Zou, Jing

AU - Zhang, Zhongfu

AU - Yang, Ruilin

AU - Zhao, Jun

AU - Xu, Congjie

AU - Yin, Weihua

AU - Guan, Zhichen

AU - Ye, Jiongxian

AU - Zhang, Hong

AU - Li, Jingxiang

AU - Kristiansen, Karsten

AU - Nickerson, Michael L

AU - Theodorescu, Dan

AU - Li, Yingrui

AU - Zhang, Xiuqing

AU - Li, Songgang

AU - Wang, Jian

AU - Yang, Huanming

AU - Wang, Jun

AU - Cai, Zhiming

PY - 2011

Y1 - 2011

N2 - Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.

AB - Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.

KW - Carcinoma, Transitional Cell

KW - Chromatin Assembly and Disassembly

KW - Chromosome Aberrations

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mutation

KW - Urinary Bladder Neoplasms

U2 - 10.1038/ng.907

DO - 10.1038/ng.907

M3 - Letter

C2 - 21822268

VL - 43

SP - 875

EP - 878

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

ER -