TY - JOUR
T1 - From workout to molecular switches
T2 - How does skeletal muscle produce, sense, and transduce subcellular redox signals?
AU - Henriquez-Olguin, Carlos
AU - Meneses-Valdes, Roberto
AU - Kritsiligkou, Paraskevi
AU - Fuentes-Lemus, Eduardo
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Skeletal muscle is crucial for maintaining human health and overall quality of life. Acute exercise introduces a multifaceted intracellular stress, with numerous post-translational modifications believed to underpin the health benefits of sustained exercise training. Reactive oxygen species (ROS) are posited to serve as second messengers, triggering cytoprotective adaptations such as the upregulation of enzymatic scavenger systems. However, a significant knowledge gap exists between the generation of oxidants in muscle and the exact mechanisms driving muscle adaptations. This review delves into the current research on subcellular redox biochemistry and its role in the physiological adaptations to exercise. We propose that the subcellular regulation of specific redox modifications is key to ensuring specificity in the intracellular response.
AB - Skeletal muscle is crucial for maintaining human health and overall quality of life. Acute exercise introduces a multifaceted intracellular stress, with numerous post-translational modifications believed to underpin the health benefits of sustained exercise training. Reactive oxygen species (ROS) are posited to serve as second messengers, triggering cytoprotective adaptations such as the upregulation of enzymatic scavenger systems. However, a significant knowledge gap exists between the generation of oxidants in muscle and the exact mechanisms driving muscle adaptations. This review delves into the current research on subcellular redox biochemistry and its role in the physiological adaptations to exercise. We propose that the subcellular regulation of specific redox modifications is key to ensuring specificity in the intracellular response.
KW - Exercise training
KW - Hydrogen peroxide
KW - Mitochondria
KW - Redox signaling
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85175547049&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2023.10.404
DO - 10.1016/j.freeradbiomed.2023.10.404
M3 - Review
C2 - 37923089
AN - SCOPUS:85175547049
VL - 209
SP - 355
EP - 365
JO - Free Radical Biology & Medicine
JF - Free Radical Biology & Medicine
SN - 0891-5849
ER -