TY - JOUR
T1 - Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine
AU - Myren, Maja
AU - Baun, Michael
AU - Ploug, Kenneth Beri
AU - Jansen-Olesen, Inger
AU - Olesen, Jes
AU - Gupta, Saurabh
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.
AB - Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.
U2 - http://dx.doi.org/10.1177/0333102409357957
DO - http://dx.doi.org/10.1177/0333102409357957
M3 - Journal article
VL - 30
SP - 1110
EP - 1122
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 9
ER -