TY - JOUR
T1 - Gastrointestinal applications of iodine quantification using dual-energy CT
T2 - A systematic review
AU - Xu, Jack Junchi
AU - Taudorf, Mikkel
AU - Ulriksen, Peter Sommer
AU - Achiam, Michael Patrick
AU - Resch, Timothy Andrew
AU - Nielsen, Michael Bachmann
AU - Lönn, Lars Birger
AU - Hansen, Kristoffer Lindskov
PY - 2020
Y1 - 2020
N2 - Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointestinal tract using DECT. The search was conducted with three databases: EMBASE, Pubmed and The Cochrane Library. This identified 449 studies after duplicate removal. From a total of 570 selected studies, 30 studies were enrolled for the systematic review. The studies were categorized into four main topics: gastric tumors (12 studies), colorectal tumors (8 studies), Crohn’s disease (4 studies) and miscellaneous applications (6 studies). Findings included a significant difference in iodine concentration (IC) measurements in perigastric fat between T1–3 vs. T4 stage gastric cancer, poorly and well differentiated gastric and colorectal cancer, responders vs. non-responders following chemo- or chemoradiotherapy treatment among cancer patients, and a positive correlation between IC and Crohn’s disease activity. In conclusion, iodine quantification with DECT may be used preoperatively in cancer imaging as well as for monitoring treatment response. Future studies are warranted to evaluate the capabilities and limitations of DECT in splanchnic flow.
AB - Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointestinal tract using DECT. The search was conducted with three databases: EMBASE, Pubmed and The Cochrane Library. This identified 449 studies after duplicate removal. From a total of 570 selected studies, 30 studies were enrolled for the systematic review. The studies were categorized into four main topics: gastric tumors (12 studies), colorectal tumors (8 studies), Crohn’s disease (4 studies) and miscellaneous applications (6 studies). Findings included a significant difference in iodine concentration (IC) measurements in perigastric fat between T1–3 vs. T4 stage gastric cancer, poorly and well differentiated gastric and colorectal cancer, responders vs. non-responders following chemo- or chemoradiotherapy treatment among cancer patients, and a positive correlation between IC and Crohn’s disease activity. In conclusion, iodine quantification with DECT may be used preoperatively in cancer imaging as well as for monitoring treatment response. Future studies are warranted to evaluate the capabilities and limitations of DECT in splanchnic flow.
KW - Dual-energy CT
KW - Gastrointestinal diseases
KW - Gastrointestinal tract
KW - Iodine concentration
KW - Iodine quantification
KW - Tumor differentiation
U2 - 10.3390/diagnostics10100814
DO - 10.3390/diagnostics10100814
M3 - Review
C2 - 33066281
AN - SCOPUS:85092689963
VL - 10
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 10
M1 - 814
ER -