Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes

L H Larsen, C S Rose, T Sparsø, J Overgaard, Signe Sørensen Torekov, N Grarup, D P Jensen, Anders Albrechtsen, G Andersen, J Ek, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

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14 Citations (Scopus)

Abstract

The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.
Original languageEnglish
JournalInternational Journal of Obesity
Volume31
Issue number2
Pages (from-to)365-70
Number of pages6
ISSN0307-0565
DOIs
Publication statusPublished - 2007

Keywords

  • Aged
  • Anthropometry
  • Blood Glucose
  • Body Constitution
  • Chromosomes, Human, Pair 11
  • DNA Mutational Analysis
  • Diabetes Mellitus, Type 2
  • Estrogen Receptor alpha
  • Female
  • Genetic Predisposition to Disease
  • Heat-Shock Proteins
  • Humans
  • Insulin
  • Linkage Disequilibrium
  • Lipids
  • Male
  • Middle Aged
  • Obesity
  • Polymorphism, Single Nucleotide
  • Quantitative Trait, Heritable
  • Transcription Factors

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