TY - JOUR
T1 - Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain
AU - Fordyce, Sarah Louise
AU - Bragstad, Karoline
AU - Pedersen, Svend Stenvang
AU - Jensen, Thøger G.
AU - Gahrn-Hansen, Bente
AU - Daniels, Rod
AU - Hay, Alan
AU - Kampmann, Marie-Louise
AU - Bruhn, Christian Anders Wathne
AU - Moreno Mayar, José Victor
AU - Avila Arcos, Maria del Carmen
AU - Gilbert, Tom
AU - Nielsen, Lars P.
PY - 2013
Y1 - 2013
N2 - Influenza viruses such as swine-origin influenza A(H1N1) virus (A(H1N1)pdm09) generate genetic diversity due to the high error rate of their RNA polymerase, often resulting in mixed genotype populations (intra-host variants) within a single infection. This variation helps influenza to rapidly respond to selection pressures, such as those imposed by the immunological host response and antiviral therapy. We have applied deep sequencing to characterize influenza intra-host variation in a transmission chain consisting of three cases due to oseltamivir-sensitive viruses, and one derived oseltamivir-resistant case.
AB - Influenza viruses such as swine-origin influenza A(H1N1) virus (A(H1N1)pdm09) generate genetic diversity due to the high error rate of their RNA polymerase, often resulting in mixed genotype populations (intra-host variants) within a single infection. This variation helps influenza to rapidly respond to selection pressures, such as those imposed by the immunological host response and antiviral therapy. We have applied deep sequencing to characterize influenza intra-host variation in a transmission chain consisting of three cases due to oseltamivir-sensitive viruses, and one derived oseltamivir-resistant case.
U2 - 10.1186/1743-422X-10-116
DO - 10.1186/1743-422X-10-116
M3 - Journal article
C2 - 23587185
VL - 10
JO - Virology Journal
JF - Virology Journal
SN - 1743-422X
M1 - 116
ER -