Abstract
Polysaccharide-protein nanocomplexes are considered one of the desired systems to encapsulate bioactive compounds. The study prepared chitosan (CS)/genipin (GP)/zein nanoparticles with chemical cross-linkage for encapsulating and releasing curcumin. Fourier transform infrared spectra demonstrated that cross-linkage between molecules was attributed to electrostatic interactions and the formation of amido bonds and hydrogen bonding. Transmission electron microscopy showed that all prepared nanoparticles showed a spherical morphology. Particularly, cinnamaldehyde screening –NH2 groups in CS significantly reduced the encapsulation efficiency of nanoparticles, demonstrating the significant role of the –NH2 group in CS-coated zein nanoparticles. Additionally, the encapsulation efficiency was largely increased to 82.3 % at the ratio of CS/GP/zein (w/w, 20:1:100), compared with 38.4 % using zein as a single encapsulation for curcumin. In vitro digestion, the addition of GP and CS decreased the release of curcumin from 84.8 % to 57.1 % after the initial digestion of 2 h. The GP/CS/zein particles retained 12 % of curcumin after 6- h of digestion, indicating the improvements in encapsulation efficiency and release properties.
Original language | English |
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Article number | 138555 |
Journal | International Journal of Biological Macromolecules |
Volume | 288 |
ISSN | 0141-8130 |
DOIs | |
Publication status | Published - Feb 2025 |
Bibliographical note
Funding Information:This study was financially supported by the development fund of Zhejiang A & F University ( 2020FR082 ).
Publisher Copyright:
© 2024 Elsevier B.V.
Keywords
- Chitosan
- Encapsulation
- Genipin
- Nanoparticles
- Zein