TY - JOUR
T1 - Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts
AU - Rasmussen, Jacob A.
AU - Villumsen, Kasper R.
AU - Duchêne, David A.
AU - Puetz, Lara C.
AU - Delmont, Tom O.
AU - Sveier, Harald
AU - Jørgensen, Louise von Gersdorff
AU - Præbel, Kim
AU - Martin, Michael D.
AU - Bojesen, Anders M.
AU - Gilbert, M. Thomas P.
AU - Kristiansen, Karsten
AU - Limborg, Morten T.
PY - 2021
Y1 - 2021
N2 - Salmonids are important sources of protein for a large proportion of the human population. Mycoplasma species are a major constituent of the gut microbiota of salmonids, often representing the majority of microbiota. Despite the frequent reported dominance of salmonid-related Mycoplasma species, little is known about the phylogenomic placement, functions and potential evolutionary relationships with their salmonid hosts. In this study, we utilise 2.9 billion metagenomic reads generated from 12 samples from three different salmonid host species to I) characterise and curate the first metagenome-assembled genomes (MAGs) of Mycoplasma dominating the intestines of three different salmonid species, II) establish the phylogeny of these salmonid candidate Mycoplasma species, III) perform a comprehensive pangenomic analysis of Mycoplasma, IV) decipher the putative functionalities of the salmonid MAGs and reveal specific functions expected to benefit the host. Our data provide a basis for future studies examining the composition and function of the salmonid microbiota.
AB - Salmonids are important sources of protein for a large proportion of the human population. Mycoplasma species are a major constituent of the gut microbiota of salmonids, often representing the majority of microbiota. Despite the frequent reported dominance of salmonid-related Mycoplasma species, little is known about the phylogenomic placement, functions and potential evolutionary relationships with their salmonid hosts. In this study, we utilise 2.9 billion metagenomic reads generated from 12 samples from three different salmonid host species to I) characterise and curate the first metagenome-assembled genomes (MAGs) of Mycoplasma dominating the intestines of three different salmonid species, II) establish the phylogeny of these salmonid candidate Mycoplasma species, III) perform a comprehensive pangenomic analysis of Mycoplasma, IV) decipher the putative functionalities of the salmonid MAGs and reveal specific functions expected to benefit the host. Our data provide a basis for future studies examining the composition and function of the salmonid microbiota.
U2 - 10.1038/s42003-021-02105-1
DO - 10.1038/s42003-021-02105-1
M3 - Journal article
C2 - 33990699
VL - 4
JO - Communications Biology
JF - Communications Biology
SN - 2399-3642
M1 - 579
ER -