Genome-wide association study identifies four loci associated with eruption of permanent teeth

Frank Geller; Bjarke Feenstra; Hao Zhang; John R Shaffer; Thomas Hansen; Ann-Louise Esserlind; Heather A Boyd; Ellen A Nohr; Nicholas J Timpson; Ghazaleh Fatemifar; Lavinia Paternoster; David M Evans; Robert J Weyant; Steven M Levy; Mark Lathrop; George Davey Smith; Jeffrey C Murray; Jes Olesen; Thomas Mears Werge; Mary L Marazita; Thorkild I A Sørensen; Mads Melbye

doi:10.1371/journal.pgen.1002275

Genome-wide association study identifies four loci associated with eruption of permanent teeth

Frank Geller, Bjarke Feenstra, Hao Zhang, John R Shaffer, Thomas Hansen, Ann-Louise Esserlind, Heather A Boyd, Ellen A Nohr, Nicholas J Timpson, Ghazaleh Fatemifar, Lavinia Paternoster, David M Evans, Robert J Weyant, Steven M Levy, Mark Lathrop, George Davey Smith, Jeffrey C Murray, Jes Olesen, Thomas Mears Werge, Mary L MarazitaThorkild I A Sørensen, Mads Melbye

Graduate School of Health and Medical Sciences

Research output: Contribution to journal › Journal article › Research › peer-review

31 Citations (Scopus)

Abstract

The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P

Original language	English
Journal	P L o S Genetics
Volume	7
Issue number	9
Pages (from-to)	e1002275
ISSN	1553-7390
DOIs	https://doi.org/10.1371/journal.pgen.1002275 https://doi.org/10.1371/journal.pgen.1002275
Publication status	Published - 1 Sep 2011

Access to Document

Cite this

Geller, F., Feenstra, B., Zhang, H., Shaffer, J. R., Hansen, T., Esserlind, A-L., Boyd, H. A., Nohr, E. A., Timpson, N. J., Fatemifar, G., Paternoster, L., Evans, D. M., Weyant, R. J., Levy, S. M., Lathrop, M., Smith, G. D., Murray, J. C., Olesen, J., Werge, T. M., ... Melbye, M. (2011). Genome-wide association study identifies four loci associated with eruption of permanent teeth. P L o S Genetics, 7(9), e1002275. https://doi.org/10.1371/journal.pgen.1002275, https://doi.org/10.1371/journal.pgen.1002275

Genome-wide association study identifies four loci associated with eruption of permanent teeth. / Geller, Frank; Feenstra, Bjarke; Zhang, Hao; Shaffer, John R; Hansen, Thomas; Esserlind, Ann-Louise; Boyd, Heather A; Nohr, Ellen A; Timpson, Nicholas J; Fatemifar, Ghazaleh; Paternoster, Lavinia; Evans, David M; Weyant, Robert J; Levy, Steven M; Lathrop, Mark; Smith, George Davey; Murray, Jeffrey C; Olesen, Jes ; Werge, Thomas Mears; Marazita, Mary L; Sørensen, Thorkild I A; Melbye, Mads.

In: P L o S Genetics, Vol. 7, No. 9, 01.09.2011, p. e1002275.

Research output: Contribution to journal › Journal article › Research › peer-review

Geller, F, Feenstra, B, Zhang, H, Shaffer, JR, Hansen, T, Esserlind, A-L, Boyd, HA, Nohr, EA, Timpson, NJ, Fatemifar, G, Paternoster, L, Evans, DM, Weyant, RJ, Levy, SM, Lathrop, M, Smith, GD, Murray, JC, Olesen, J , Werge, TM, Marazita, ML, Sørensen, TIA & Melbye, M 2011, 'Genome-wide association study identifies four loci associated with eruption of permanent teeth', P L o S Genetics, vol. 7, no. 9, pp. e1002275. https://doi.org/10.1371/journal.pgen.1002275, https://doi.org/10.1371/journal.pgen.1002275

Geller, Frank ; Feenstra, Bjarke ; Zhang, Hao ; Shaffer, John R ; Hansen, Thomas ; Esserlind, Ann-Louise ; Boyd, Heather A ; Nohr, Ellen A ; Timpson, Nicholas J ; Fatemifar, Ghazaleh ; Paternoster, Lavinia ; Evans, David M ; Weyant, Robert J ; Levy, Steven M ; Lathrop, Mark ; Smith, George Davey ; Murray, Jeffrey C ; Olesen, Jes ; Werge, Thomas Mears ; Marazita, Mary L ; Sørensen, Thorkild I A ; Melbye, Mads. / Genome-wide association study identifies four loci associated with eruption of permanent teeth. In: P L o S Genetics. 2011 ; Vol. 7, No. 9. pp. e1002275.

@article{92f0d0cd40084f20b2cb601dd282e05a,

title = "Genome-wide association study identifies four loci associated with eruption of permanent teeth",

abstract = "The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P",

author = "Frank Geller and Bjarke Feenstra and Hao Zhang and Shaffer, {John R} and Thomas Hansen and Ann-Louise Esserlind and Boyd, {Heather A} and Nohr, {Ellen A} and Timpson, {Nicholas J} and Ghazaleh Fatemifar and Lavinia Paternoster and Evans, {David M} and Weyant, {Robert J} and Levy, {Steven M} and Mark Lathrop and Smith, {George Davey} and Murray, {Jeffrey C} and Jes Olesen and Werge, {Thomas Mears} and Marazita, {Mary L} and S{\o}rensen, {Thorkild I A} and Mads Melbye",

year = "2011",

month = sep,

day = "1",

doi = "10.1371/journal.pgen.1002275",

language = "English",

volume = "7",

pages = "e1002275",

journal = "P L o S Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

number = "9",

}

TY - JOUR

T1 - Genome-wide association study identifies four loci associated with eruption of permanent teeth

AU - Geller, Frank

AU - Feenstra, Bjarke

AU - Zhang, Hao

AU - Shaffer, John R

AU - Hansen, Thomas

AU - Esserlind, Ann-Louise

AU - Boyd, Heather A

AU - Nohr, Ellen A

AU - Timpson, Nicholas J

AU - Fatemifar, Ghazaleh

AU - Paternoster, Lavinia

AU - Evans, David M

AU - Weyant, Robert J

AU - Levy, Steven M

AU - Lathrop, Mark

AU - Smith, George Davey

AU - Murray, Jeffrey C

AU - Olesen, Jes

AU - Werge, Thomas Mears

AU - Marazita, Mary L

AU - Sørensen, Thorkild I A

AU - Melbye, Mads

PY - 2011/9/1

Y1 - 2011/9/1

N2 - The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P

AB - The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P

U2 - 10.1371/journal.pgen.1002275

DO - 10.1371/journal.pgen.1002275

M3 - Journal article

C2 - 21931568

VL - 7

SP - e1002275

JO - P L o S Genetics

JF - P L o S Genetics

SN - 1553-7390

IS - 9

ER -