Genomic evidence for the Pleistocene and recent population history of Native Americans

Maanasa Raghavan; Matthias Steinrücken; Kelley Harris; Stephan Schiffels; Simon Rasmussen; Michael DeGiorgio; Anders Albrechtsen; Cristina E. Valdiosera Morales; Maria del Carmen Avila Arcos; Anna Sapfo Malaspinas; Anders Eriksson; Ida Moltke; Mait Metspalu; Julian R Homburger; Jeff Wall; Omar E Cornejo; José Victor Moreno Mayar; Thorfinn Sand Korneliussen; Tracey Lynn Pierre; Morten Rasmussen; Paula Campos; Peter de Barros Damgaard; Morten Erik Allentoft; John Lindo; Ene Metspalu; Ricardo Rodríguez-Varela; Josefina Mansilla; Celeste Henrickson; Andaine Seguin-Orlando; Helena Malmström; Thomas Stafford jr.; Suyash S Shringarpure; Andrés Moreno-Estrada; Monika Karmin; Kristiina Tambets; Anders Bergström; Yali Xue; Vera Warmuth; Andrew D Friend; Joy Singarayer; Paul Valdes; Francois Balloux; Ilán Leboreiro; Jose Luis Vera; Hector Rangel-Villalobos; Davide Pettener; Donata Luiselli; Loren G Davis; Evelyne Heyer; Christoph P E Zollikofer; Marcia S Ponce de León; Colin I Smith; Vaughan Grimes; Kelly-Anne Pike; Michael Deal; Benjamin T Fuller; Bernardo Arriaza; Vivien Standen; Maria F Luz; Francois Ricaut; Niede Guidon; Ludmila Osipova; Mikhail I Voevoda; Olga L Posukh; Oleg Balanovsky; Maria Lavryashina; Yuri Bogunov; Elza Khusnutdinova; Marina Gubina; Elena Balanovska; Sardana Fedorova; Sergey Litvinov; Boris Malyarchuk; Miroslava Derenko; M J Mosher; David Archer; Jerome Cybulski; Barbara Petzelt; Joycelynn Mitchell; Rosita Worl; Paul J Norman; Peter Parham; Brian M Kemp; Toomas Kivisild; Chris Tyler-Smith; Manjinder S Sandhu; Michael Crawford; Richard Villems; David Glenn Smith; Michael R Waters; Ted Goebel; John R Johnson; Ripan S Malhi; Mattias Jakobsson; David J. Meltzer; Andrea Manica; Richard Durbin; Carlos D Bustamante; Yun S Song; Rasmus Nielsen; Eske Willerslev

doi:10.1126/science.aab3884

Genomic evidence for the Pleistocene and recent population history of Native Americans

Maanasa Raghavan, Matthias Steinrücken, Kelley Harris, Stephan Schiffels, Simon Rasmussen, Michael DeGiorgio, Anders Albrechtsen, Cristina E. Valdiosera Morales, Maria del Carmen Avila Arcos, Anna Sapfo Malaspinas, Anders Eriksson, Ida Moltke, Mait Metspalu, Julian R Homburger, Jeff Wall, Omar E Cornejo, José Victor Moreno Mayar, Thorfinn Sand Korneliussen, Tracey Lynn Pierre, Morten RasmussenPaula Campos, Peter de Barros Damgaard, Morten Erik Allentoft, John Lindo, Ene Metspalu, Ricardo Rodríguez-Varela, Josefina Mansilla, Celeste Henrickson, Andaine Seguin-Orlando, Helena Malmström, Thomas Stafford jr., Suyash S Shringarpure, Andrés Moreno-Estrada, Monika Karmin, Kristiina Tambets, Anders Bergström, Yali Xue, Vera Warmuth, Andrew D Friend, Joy Singarayer, Paul Valdes, Francois Balloux, Ilán Leboreiro, Jose Luis Vera, Hector Rangel-Villalobos, Davide Pettener, Donata Luiselli, Loren G Davis, Evelyne Heyer, Christoph P E Zollikofer, Marcia S Ponce de León, Colin I Smith, Vaughan Grimes, Kelly-Anne Pike, Michael Deal, Benjamin T Fuller, Bernardo Arriaza, Vivien Standen, Maria F Luz, Francois Ricaut, Niede Guidon, Ludmila Osipova, Mikhail I Voevoda, Olga L Posukh, Oleg Balanovsky, Maria Lavryashina, Yuri Bogunov, Elza Khusnutdinova, Marina Gubina, Elena Balanovska, Sardana Fedorova, Sergey Litvinov, Boris Malyarchuk, Miroslava Derenko, M J Mosher, David Archer, Jerome Cybulski, Barbara Petzelt, Joycelynn Mitchell, Rosita Worl, Paul J Norman, Peter Parham, Brian M Kemp, Toomas Kivisild, Chris Tyler-Smith, Manjinder S Sandhu, Michael Crawford, Richard Villems, David Glenn Smith, Michael R Waters, Ted Goebel, John R Johnson, Ripan S Malhi, Mattias Jakobsson, David J. Meltzer, Andrea Manica, Richard Durbin, Carlos D Bustamante, Yun S Song, Rasmus Nielsen, Eske Willerslev

Computational and RNA Biology

Research output: Contribution to journal › Journal article › Research › peer-review

372 Citations (Scopus)

Abstract

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.

Original language	English
Article number	6250
Journal	Science (New York, N.Y.)
Volume	349
Issue number	6250
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.aab3884
Publication status	Published - 2015

Access to Document

10.1126/science.aab3884

Cite this

Raghavan, M., Steinrücken, M., Harris, K., Schiffels, S., Rasmussen, S., DeGiorgio, M., Albrechtsen, A., Valdiosera Morales, C. E., Avila Arcos, M. D. C., Malaspinas, A. S., Eriksson, A., Moltke, I., Metspalu, M., Homburger, J. R., Wall, J., Cornejo, O. E., Moreno Mayar, J. V., Korneliussen, T. S., Pierre, T. L., ... Willerslev, E. (2015). Genomic evidence for the Pleistocene and recent population history of Native Americans. Science (New York, N.Y.), 349(6250), [6250]. https://doi.org/10.1126/science.aab3884

Genomic evidence for the Pleistocene and recent population history of Native Americans. / Raghavan, Maanasa; Steinrücken, Matthias; Harris, Kelley; Schiffels, Stephan; Rasmussen, Simon; DeGiorgio, Michael; Albrechtsen, Anders; Valdiosera Morales, Cristina E.; Avila Arcos, Maria del Carmen; Malaspinas, Anna Sapfo; Eriksson, Anders; Moltke, Ida; Metspalu, Mait; Homburger, Julian R; Wall, Jeff; Cornejo, Omar E; Moreno Mayar, José Victor ; Korneliussen, Thorfinn Sand; Pierre, Tracey Lynn; Rasmussen, Morten; Campos, Paula; Damgaard, Peter de Barros; Allentoft, Morten Erik; Lindo, John; Metspalu, Ene; Rodríguez-Varela, Ricardo; Mansilla, Josefina; Henrickson, Celeste; Seguin-Orlando, Andaine; Malmström, Helena; Stafford jr., Thomas; Shringarpure, Suyash S; Moreno-Estrada, Andrés; Karmin, Monika; Tambets, Kristiina; Bergström, Anders; Xue, Yali; Warmuth, Vera; Friend, Andrew D; Singarayer, Joy; Valdes, Paul; Balloux, Francois; Leboreiro, Ilán; Vera, Jose Luis; Rangel-Villalobos, Hector; Pettener, Davide; Luiselli, Donata; Davis, Loren G; Heyer, Evelyne; Zollikofer, Christoph P E; Ponce de León, Marcia S; Smith, Colin I; Grimes, Vaughan; Pike, Kelly-Anne; Deal, Michael; Fuller, Benjamin T; Arriaza, Bernardo; Standen, Vivien; Luz, Maria F; Ricaut, Francois; Guidon, Niede; Osipova, Ludmila; Voevoda, Mikhail I; Posukh, Olga L; Balanovsky, Oleg; Lavryashina, Maria; Bogunov, Yuri; Khusnutdinova, Elza; Gubina, Marina; Balanovska, Elena; Fedorova, Sardana; Litvinov, Sergey; Malyarchuk, Boris; Derenko, Miroslava; Mosher, M J; Archer, David; Cybulski, Jerome; Petzelt, Barbara; Mitchell, Joycelynn; Worl, Rosita; Norman, Paul J; Parham, Peter; Kemp, Brian M; Kivisild, Toomas; Tyler-Smith, Chris; Sandhu, Manjinder S; Crawford, Michael; Villems, Richard; Smith, David Glenn; Waters, Michael R; Goebel, Ted; Johnson, John R; Malhi, Ripan S; Jakobsson, Mattias; Meltzer, David J.; Manica, Andrea; Durbin, Richard; Bustamante, Carlos D; Song, Yun S; Nielsen, Rasmus ; Willerslev, Eske.

In: Science (New York, N.Y.), Vol. 349, No. 6250, 6250, 2015.

Research output: Contribution to journal › Journal article › Research › peer-review

Raghavan, M, Steinrücken, M, Harris, K, Schiffels, S, Rasmussen, S, DeGiorgio, M, Albrechtsen, A, Valdiosera Morales, CE, Avila Arcos, MDC, Malaspinas, AS, Eriksson, A, Moltke, I, Metspalu, M, Homburger, JR, Wall, J, Cornejo, OE, Moreno Mayar, JV , Korneliussen, TS, Pierre, TL, Rasmussen, M, Campos, P, Damgaard, PDB, Allentoft, ME, Lindo, J, Metspalu, E, Rodríguez-Varela, R, Mansilla, J, Henrickson, C, Seguin-Orlando, A, Malmström, H, Stafford jr., T, Shringarpure, SS, Moreno-Estrada, A, Karmin, M, Tambets, K, Bergström, A, Xue, Y, Warmuth, V, Friend, AD, Singarayer, J, Valdes, P, Balloux, F, Leboreiro, I, Vera, JL, Rangel-Villalobos, H, Pettener, D, Luiselli, D, Davis, LG, Heyer, E, Zollikofer, CPE, Ponce de León, MS, Smith, CI, Grimes, V, Pike, K-A, Deal, M, Fuller, BT, Arriaza, B, Standen, V, Luz, MF, Ricaut, F, Guidon, N, Osipova, L, Voevoda, MI, Posukh, OL, Balanovsky, O, Lavryashina, M, Bogunov, Y, Khusnutdinova, E, Gubina, M, Balanovska, E, Fedorova, S, Litvinov, S, Malyarchuk, B, Derenko, M, Mosher, MJ, Archer, D, Cybulski, J, Petzelt, B, Mitchell, J, Worl, R, Norman, PJ, Parham, P, Kemp, BM, Kivisild, T, Tyler-Smith, C, Sandhu, MS, Crawford, M, Villems, R, Smith, DG, Waters, MR, Goebel, T, Johnson, JR, Malhi, RS, Jakobsson, M, Meltzer, DJ, Manica, A, Durbin, R, Bustamante, CD, Song, YS, Nielsen, R & Willerslev, E 2015, 'Genomic evidence for the Pleistocene and recent population history of Native Americans', Science (New York, N.Y.), vol. 349, no. 6250, 6250. https://doi.org/10.1126/science.aab3884

Raghavan, Maanasa ; Steinrücken, Matthias ; Harris, Kelley ; Schiffels, Stephan ; Rasmussen, Simon ; DeGiorgio, Michael ; Albrechtsen, Anders ; Valdiosera Morales, Cristina E. ; Avila Arcos, Maria del Carmen ; Malaspinas, Anna Sapfo ; Eriksson, Anders ; Moltke, Ida ; Metspalu, Mait ; Homburger, Julian R ; Wall, Jeff ; Cornejo, Omar E ; Moreno Mayar, José Victor ; Korneliussen, Thorfinn Sand ; Pierre, Tracey Lynn ; Rasmussen, Morten ; Campos, Paula ; Damgaard, Peter de Barros ; Allentoft, Morten Erik ; Lindo, John ; Metspalu, Ene ; Rodríguez-Varela, Ricardo ; Mansilla, Josefina ; Henrickson, Celeste ; Seguin-Orlando, Andaine ; Malmström, Helena ; Stafford jr., Thomas ; Shringarpure, Suyash S ; Moreno-Estrada, Andrés ; Karmin, Monika ; Tambets, Kristiina ; Bergström, Anders ; Xue, Yali ; Warmuth, Vera ; Friend, Andrew D ; Singarayer, Joy ; Valdes, Paul ; Balloux, Francois ; Leboreiro, Ilán ; Vera, Jose Luis ; Rangel-Villalobos, Hector ; Pettener, Davide ; Luiselli, Donata ; Davis, Loren G ; Heyer, Evelyne ; Zollikofer, Christoph P E ; Ponce de León, Marcia S ; Smith, Colin I ; Grimes, Vaughan ; Pike, Kelly-Anne ; Deal, Michael ; Fuller, Benjamin T ; Arriaza, Bernardo ; Standen, Vivien ; Luz, Maria F ; Ricaut, Francois ; Guidon, Niede ; Osipova, Ludmila ; Voevoda, Mikhail I ; Posukh, Olga L ; Balanovsky, Oleg ; Lavryashina, Maria ; Bogunov, Yuri ; Khusnutdinova, Elza ; Gubina, Marina ; Balanovska, Elena ; Fedorova, Sardana ; Litvinov, Sergey ; Malyarchuk, Boris ; Derenko, Miroslava ; Mosher, M J ; Archer, David ; Cybulski, Jerome ; Petzelt, Barbara ; Mitchell, Joycelynn ; Worl, Rosita ; Norman, Paul J ; Parham, Peter ; Kemp, Brian M ; Kivisild, Toomas ; Tyler-Smith, Chris ; Sandhu, Manjinder S ; Crawford, Michael ; Villems, Richard ; Smith, David Glenn ; Waters, Michael R ; Goebel, Ted ; Johnson, John R ; Malhi, Ripan S ; Jakobsson, Mattias ; Meltzer, David J. ; Manica, Andrea ; Durbin, Richard ; Bustamante, Carlos D ; Song, Yun S ; Nielsen, Rasmus ; Willerslev, Eske. / Genomic evidence for the Pleistocene and recent population history of Native Americans. In: Science (New York, N.Y.). 2015 ; Vol. 349, No. 6250.

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title = "Genomic evidence for the Pleistocene and recent population history of Native Americans",

abstract = "How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative {"}Paleoamerican{"} relict populations, including the historical Mexican Peric{\'u}es and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.",

keywords = "Americas, Gene Flow, Genomics, History, Ancient, Human Migration, Humans, Indians, North American, Models, Genetic, Siberia",

author = "Maanasa Raghavan and Matthias Steinr{\"u}cken and Kelley Harris and Stephan Schiffels and Simon Rasmussen and Michael DeGiorgio and Anders Albrechtsen and {Valdiosera Morales}, {Cristina E.} and {Avila Arcos}, {Maria del Carmen} and Malaspinas, {Anna Sapfo} and Anders Eriksson and Ida Moltke and Mait Metspalu and Homburger, {Julian R} and Jeff Wall and Cornejo, {Omar E} and {Moreno Mayar}, {Jos{\'e} Victor} and Korneliussen, {Thorfinn Sand} and Pierre, {Tracey Lynn} and Morten Rasmussen and Paula Campos and Damgaard, {Peter de Barros} and Allentoft, {Morten Erik} and John Lindo and Ene Metspalu and Ricardo Rodr{\'i}guez-Varela and Josefina Mansilla and Celeste Henrickson and Andaine Seguin-Orlando and Helena Malmstr{\"o}m and {Stafford jr.}, Thomas and Shringarpure, {Suyash S} and Andr{\'e}s Moreno-Estrada and Monika Karmin and Kristiina Tambets and Anders Bergstr{\"o}m and Yali Xue and Vera Warmuth and Friend, {Andrew D} and Joy Singarayer and Paul Valdes and Francois Balloux and Il{\'a}n Leboreiro and Vera, {Jose Luis} and Hector Rangel-Villalobos and Davide Pettener and Donata Luiselli and Davis, {Loren G} and Evelyne Heyer and Zollikofer, {Christoph P E} and {Ponce de Le{\'o}n}, {Marcia S} and Smith, {Colin I} and Vaughan Grimes and Kelly-Anne Pike and Michael Deal and Fuller, {Benjamin T} and Bernardo Arriaza and Vivien Standen and Luz, {Maria F} and Francois Ricaut and Niede Guidon and Ludmila Osipova and Voevoda, {Mikhail I} and Posukh, {Olga L} and Oleg Balanovsky and Maria Lavryashina and Yuri Bogunov and Elza Khusnutdinova and Marina Gubina and Elena Balanovska and Sardana Fedorova and Sergey Litvinov and Boris Malyarchuk and Miroslava Derenko and Mosher, {M J} and David Archer and Jerome Cybulski and Barbara Petzelt and Joycelynn Mitchell and Rosita Worl and Norman, {Paul J} and Peter Parham and Kemp, {Brian M} and Toomas Kivisild and Chris Tyler-Smith and Sandhu, {Manjinder S} and Michael Crawford and Richard Villems and Smith, {David Glenn} and Waters, {Michael R} and Ted Goebel and Johnson, {John R} and Malhi, {Ripan S} and Mattias Jakobsson and Meltzer, {David J.} and Andrea Manica and Richard Durbin and Bustamante, {Carlos D} and Song, {Yun S} and Rasmus Nielsen and Eske Willerslev",

note = "Copyright {\textcopyright} 2015, American Association for the Advancement of Science.",

year = "2015",

doi = "10.1126/science.aab3884",

language = "English",

volume = "349",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6250",

}

TY - JOUR

T1 - Genomic evidence for the Pleistocene and recent population history of Native Americans

AU - Raghavan, Maanasa

AU - Steinrücken, Matthias

AU - Harris, Kelley

AU - Schiffels, Stephan

AU - Rasmussen, Simon

AU - DeGiorgio, Michael

AU - Albrechtsen, Anders

AU - Valdiosera Morales, Cristina E.

AU - Avila Arcos, Maria del Carmen

AU - Malaspinas, Anna Sapfo

AU - Eriksson, Anders

AU - Moltke, Ida

AU - Metspalu, Mait

AU - Homburger, Julian R

AU - Wall, Jeff

AU - Cornejo, Omar E

AU - Moreno Mayar, José Victor

AU - Korneliussen, Thorfinn Sand

AU - Pierre, Tracey Lynn

AU - Rasmussen, Morten

AU - Campos, Paula

AU - Damgaard, Peter de Barros

AU - Allentoft, Morten Erik

AU - Lindo, John

AU - Metspalu, Ene

AU - Rodríguez-Varela, Ricardo

AU - Mansilla, Josefina

AU - Henrickson, Celeste

AU - Seguin-Orlando, Andaine

AU - Malmström, Helena

AU - Stafford jr., Thomas

AU - Shringarpure, Suyash S

AU - Moreno-Estrada, Andrés

AU - Karmin, Monika

AU - Tambets, Kristiina

AU - Bergström, Anders

AU - Xue, Yali

AU - Warmuth, Vera

AU - Friend, Andrew D

AU - Singarayer, Joy

AU - Valdes, Paul

AU - Balloux, Francois

AU - Leboreiro, Ilán

AU - Vera, Jose Luis

AU - Rangel-Villalobos, Hector

AU - Pettener, Davide

AU - Luiselli, Donata

AU - Davis, Loren G

AU - Heyer, Evelyne

AU - Zollikofer, Christoph P E

AU - Ponce de León, Marcia S

AU - Smith, Colin I

AU - Grimes, Vaughan

AU - Pike, Kelly-Anne

AU - Deal, Michael

AU - Fuller, Benjamin T

AU - Arriaza, Bernardo

AU - Standen, Vivien

AU - Luz, Maria F

AU - Ricaut, Francois

AU - Guidon, Niede

AU - Osipova, Ludmila

AU - Voevoda, Mikhail I

AU - Posukh, Olga L

AU - Balanovsky, Oleg

AU - Lavryashina, Maria

AU - Bogunov, Yuri

AU - Khusnutdinova, Elza

AU - Gubina, Marina

AU - Balanovska, Elena

AU - Fedorova, Sardana

AU - Litvinov, Sergey

AU - Malyarchuk, Boris

AU - Derenko, Miroslava

AU - Mosher, M J

AU - Archer, David

AU - Cybulski, Jerome

AU - Petzelt, Barbara

AU - Mitchell, Joycelynn

AU - Worl, Rosita

AU - Norman, Paul J

AU - Parham, Peter

AU - Kemp, Brian M

AU - Kivisild, Toomas

AU - Tyler-Smith, Chris

AU - Sandhu, Manjinder S

AU - Crawford, Michael

AU - Villems, Richard

AU - Smith, David Glenn

AU - Waters, Michael R

AU - Goebel, Ted

AU - Johnson, John R

AU - Malhi, Ripan S

AU - Jakobsson, Mattias

AU - Meltzer, David J.

AU - Manica, Andrea

AU - Durbin, Richard

AU - Bustamante, Carlos D

AU - Song, Yun S

AU - Nielsen, Rasmus

AU - Willerslev, Eske

PY - 2015

Y1 - 2015

N2 - How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.

AB - How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.

KW - Americas

KW - Gene Flow

KW - Genomics

KW - History, Ancient

KW - Human Migration

KW - Humans

KW - Indians, North American

KW - Models, Genetic

KW - Siberia

U2 - 10.1126/science.aab3884

DO - 10.1126/science.aab3884

M3 - Journal article

C2 - 26198033

VL - 349

JO - Science

JF - Science

SN - 0036-8075

IS - 6250

M1 - 6250

ER -