GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Simon Doessing; Lars Holm; Katja M Heinemeier; Ulla Feldt-Rasmussen; Peter Schjerling; Klaus Qvortrup; Jytte O Larsen; Rie H Nielsen; Allan Flyvbjerg; Michael Kjaer

doi:10.1530/EJE-10-0818

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients

Simon Doessing, Lars Holm, Katja M Heinemeier, Ulla Feldt-Rasmussen, Peter Schjerling, Klaus Qvortrup, Jytte O Larsen, Rie H Nielsen, Allan Flyvbjerg, Michael Kjaer

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Abstract

Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.

Original language	English
Journal	European Journal of Endocrinology
Volume	163
Issue number	6
Pages (from-to)	853-62
Number of pages	10
ISSN	0804-4643
DOIs	https://doi.org/10.1530/EJE-10-0818
Publication status	Published - Dec 2010

Keywords

Adult
Collagen
Collagen Type I
Collagen Type III
Human Growth Hormone
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Male
Microscopy, Electron, Transmission
Middle Aged
Muscle, Skeletal
RNA, Messenger
Tendons

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Doessing, S., Holm, L., Heinemeier, K. M., Feldt-Rasmussen, U., Schjerling, P., Qvortrup, K., Larsen, J. O., Nielsen, R. H., Flyvbjerg, A., & Kjaer, M. (2010). GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients. European Journal of Endocrinology, 163(6), 853-62. https://doi.org/10.1530/EJE-10-0818

Doessing, S, Holm, L, Heinemeier, KM, Feldt-Rasmussen, U, Schjerling, P , Qvortrup, K, Larsen, JO, Nielsen, RH, Flyvbjerg, A & Kjaer, M 2010, 'GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients', European Journal of Endocrinology, vol. 163, no. 6, pp. 853-62. https://doi.org/10.1530/EJE-10-0818

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abstract = "Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.",

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author = "Simon Doessing and Lars Holm and Heinemeier, {Katja M} and Ulla Feldt-Rasmussen and Peter Schjerling and Klaus Qvortrup and Larsen, {Jytte O} and Nielsen, {Rie H} and Allan Flyvbjerg and Michael Kjaer",

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AU - Doessing, Simon

AU - Holm, Lars

AU - Heinemeier, Katja M

AU - Feldt-Rasmussen, Ulla

AU - Schjerling, Peter

AU - Qvortrup, Klaus

AU - Larsen, Jytte O

AU - Nielsen, Rie H

AU - Flyvbjerg, Allan

AU - Kjaer, Michael

PY - 2010/12

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AB - Disproportionate growth of musculoskeletal tissue is a major cause of morbidity in both acromegalic (ACRO) and GH-deficient (GHD) patients. GH/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen. We hypothesized that the local production of collagen is associated with the level of GH/IGF1.

KW - Adult

KW - Collagen

KW - Collagen Type I

KW - Collagen Type III

KW - Human Growth Hormone

KW - Humans

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Insulin-Like Growth Factor I

KW - Male

KW - Microscopy, Electron, Transmission

KW - Middle Aged

KW - Muscle, Skeletal

KW - RNA, Messenger

KW - Tendons

U2 - 10.1530/EJE-10-0818

DO - 10.1530/EJE-10-0818

M3 - Journal article

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SN - 0804-4643

VL - 163

SP - 853

EP - 862

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 6

ER -