Ghrelin

T. D. Mueller; R. Nogueiras; M. L. Andermann; Z. B. Andrews; S. D. Anker; J. Argente; R. L. Batterham; S. C. Benoit; C. Y. Bowers; F. Broglio; F. F. Casanueva; D. D'Alessio; I. Depoortere; A. Geliebter; E. Ghigo; P. A. Cole; M. Cowley; D. E. Cummings; A. Dagher; S. Diano; S. L. Dickson; C. Dieguez; R. Granata; H. J. Grill; K. Grove; K. M. Habegger; K. Heppner; M. L. Heiman; L. Holsen; B. Holst; A. Inui; J. O. Jansson; H. Kirchner; M. Korbonits; B. Laferrere; C. W. LeRoux; M. Lopez; S. Morin; M. Nakazato; R. Nass; D. Perez-Tilve; P. T. Pfluger; T. W. Schwartz; R. J. Seeley; M. Sleeman; Y. Sun; L. Sussel; J. Tong; M. O. Thorner; A. J. van der Lely; L. H. T. van der Ploeg; J. M. Zigman; M. Kojima; K. Kangawa; R. G. Smith; T. Horvath; M. H. Tschoep

doi:10.1016/j.molmet.2015.03.005

Ghrelin

T. D. Mueller, R. Nogueiras, M. L. Andermann, Z. B. Andrews, S. D. Anker, J. Argente, R. L. Batterham, S. C. Benoit, C. Y. Bowers, F. Broglio, F. F. Casanueva, D. D'Alessio, I. Depoortere, A. Geliebter, E. Ghigo, P. A. Cole, M. Cowley, D. E. Cummings, A. Dagher, S. DianoS. L. Dickson, C. Dieguez, R. Granata, H. J. Grill, K. Grove, K. M. Habegger, K. Heppner, M. L. Heiman, L. Holsen, B. Holst, A. Inui, J. O. Jansson, H. Kirchner, M. Korbonits, B. Laferrere, C. W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P. T. Pfluger, T. W. Schwartz, R. J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M. O. Thorner, A. J. van der Lely, L. H. T. van der Ploeg, J. M. Zigman, M. Kojima, K. Kangawa, R. G. Smith, T. Horvath, M. H. Tschoep

Research output: Contribution to journal › Review › Research › peer-review

828 Citations (Scopus)

Abstract

Background
The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.

Scope of review
In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.

Major conclusions
In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

Original language	English
Journal	Molecular Metabolism
Volume	4
Issue number	6
Pages (from-to)	437-460
Number of pages	24
ISSN	2212-8778
DOIs	https://doi.org/10.1016/j.molmet.2015.03.005
Publication status	Published - Jun 2015

Keywords

Ghrelin
Growth hormone segretagogue receptor

Access to Document

10.1016/j.molmet.2015.03.005

Cite this

Mueller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., ... Tschoep, M. H. (2015). Ghrelin. Molecular Metabolism, 4(6), 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

Ghrelin. / Mueller, T. D.; Nogueiras, R.; Andermann, M. L.; Andrews, Z. B.; Anker, S. D.; Argente, J.; Batterham, R. L.; Benoit, S. C.; Bowers, C. Y.; Broglio, F.; Casanueva, F. F.; D'Alessio, D.; Depoortere, I.; Geliebter, A.; Ghigo, E.; Cole, P. A.; Cowley, M.; Cummings, D. E.; Dagher, A.; Diano, S.; Dickson, S. L.; Dieguez, C.; Granata, R.; Grill, H. J.; Grove, K.; Habegger, K. M.; Heppner, K.; Heiman, M. L.; Holsen, L.; Holst, B.; Inui, A.; Jansson, J. O.; Kirchner, H.; Korbonits, M.; Laferrere, B.; LeRoux, C. W.; Lopez, M.; Morin, S.; Nakazato, M.; Nass, R.; Perez-Tilve, D.; Pfluger, P. T.; Schwartz, T. W.; Seeley, R. J.; Sleeman, M.; Sun, Y.; Sussel, L.; Tong, J.; Thorner, M. O.; van der Lely, A. J.; van der Ploeg, L. H. T.; Zigman, J. M.; Kojima, M.; Kangawa, K.; Smith, R. G.; Horvath, T.; Tschoep, M. H.

In: Molecular Metabolism, Vol. 4, No. 6, 06.2015, p. 437-460.

Research output: Contribution to journal › Review › Research › peer-review

Mueller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, M, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Dieguez, C, Granata, R, Grill, HJ, Grove, K, Habegger, KM, Heppner, K, Heiman, ML, Holsen, L, Holst, B, Inui, A, Jansson, JO, Kirchner, H, Korbonits, M, Laferrere, B, LeRoux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, MO, van der Lely, AJ, van der Ploeg, LHT, Zigman, JM, Kojima, M, Kangawa, K, Smith, RG, Horvath, T & Tschoep, MH 2015, 'Ghrelin', Molecular Metabolism, vol. 4, no. 6, pp. 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

Mueller, T. D. ; Nogueiras, R. ; Andermann, M. L. ; Andrews, Z. B. ; Anker, S. D. ; Argente, J. ; Batterham, R. L. ; Benoit, S. C. ; Bowers, C. Y. ; Broglio, F. ; Casanueva, F. F. ; D'Alessio, D. ; Depoortere, I. ; Geliebter, A. ; Ghigo, E. ; Cole, P. A. ; Cowley, M. ; Cummings, D. E. ; Dagher, A. ; Diano, S. ; Dickson, S. L. ; Dieguez, C. ; Granata, R. ; Grill, H. J. ; Grove, K. ; Habegger, K. M. ; Heppner, K. ; Heiman, M. L. ; Holsen, L. ; Holst, B. ; Inui, A. ; Jansson, J. O. ; Kirchner, H. ; Korbonits, M. ; Laferrere, B. ; LeRoux, C. W. ; Lopez, M. ; Morin, S. ; Nakazato, M. ; Nass, R. ; Perez-Tilve, D. ; Pfluger, P. T. ; Schwartz, T. W. ; Seeley, R. J. ; Sleeman, M. ; Sun, Y. ; Sussel, L. ; Tong, J. ; Thorner, M. O. ; van der Lely, A. J. ; van der Ploeg, L. H. T. ; Zigman, J. M. ; Kojima, M. ; Kangawa, K. ; Smith, R. G. ; Horvath, T. ; Tschoep, M. H. / Ghrelin. In: Molecular Metabolism. 2015 ; Vol. 4, No. 6. pp. 437-460.

@article{f42407ec71d9461f9ffb3975d569f099,

title = "Ghrelin",

abstract = "BackgroundThe gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.Scope of reviewIn this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.Major conclusionsIn recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.",

keywords = "Ghrelin, Growth hormone segretagogue receptor",

author = "Mueller, {T. D.} and R. Nogueiras and Andermann, {M. L.} and Andrews, {Z. B.} and Anker, {S. D.} and J. Argente and Batterham, {R. L.} and Benoit, {S. C.} and Bowers, {C. Y.} and F. Broglio and Casanueva, {F. F.} and D. D'Alessio and I. Depoortere and A. Geliebter and E. Ghigo and Cole, {P. A.} and M. Cowley and Cummings, {D. E.} and A. Dagher and S. Diano and Dickson, {S. L.} and C. Dieguez and R. Granata and Grill, {H. J.} and K. Grove and Habegger, {K. M.} and K. Heppner and Heiman, {M. L.} and L. Holsen and B. Holst and A. Inui and Jansson, {J. O.} and H. Kirchner and M. Korbonits and B. Laferrere and LeRoux, {C. W.} and M. Lopez and S. Morin and M. Nakazato and R. Nass and D. Perez-Tilve and Pfluger, {P. T.} and Schwartz, {T. W.} and Seeley, {R. J.} and M. Sleeman and Y. Sun and L. Sussel and J. Tong and Thorner, {M. O.} and {van der Lely}, {A. J.} and {van der Ploeg}, {L. H. T.} and Zigman, {J. M.} and M. Kojima and K. Kangawa and Smith, {R. G.} and T. Horvath and Tschoep, {M. H.}",

year = "2015",

month = jun,

doi = "10.1016/j.molmet.2015.03.005",

language = "English",

volume = "4",

pages = "437--460",

journal = "Molecular Metabolism",

issn = "2212-8778",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Ghrelin

AU - Mueller, T. D.

AU - Nogueiras, R.

AU - Andermann, M. L.

AU - Andrews, Z. B.

AU - Anker, S. D.

AU - Argente, J.

AU - Batterham, R. L.

AU - Benoit, S. C.

AU - Bowers, C. Y.

AU - Broglio, F.

AU - Casanueva, F. F.

AU - D'Alessio, D.

AU - Depoortere, I.

AU - Geliebter, A.

AU - Ghigo, E.

AU - Cole, P. A.

AU - Cowley, M.

AU - Cummings, D. E.

AU - Dagher, A.

AU - Diano, S.

AU - Dickson, S. L.

AU - Dieguez, C.

AU - Granata, R.

AU - Grill, H. J.

AU - Grove, K.

AU - Habegger, K. M.

AU - Heppner, K.

AU - Heiman, M. L.

AU - Holsen, L.

AU - Holst, B.

AU - Inui, A.

AU - Jansson, J. O.

AU - Kirchner, H.

AU - Korbonits, M.

AU - Laferrere, B.

AU - LeRoux, C. W.

AU - Lopez, M.

AU - Morin, S.

AU - Nakazato, M.

AU - Nass, R.

AU - Perez-Tilve, D.

AU - Pfluger, P. T.

AU - Schwartz, T. W.

AU - Seeley, R. J.

AU - Sleeman, M.

AU - Sun, Y.

AU - Sussel, L.

AU - Tong, J.

AU - Thorner, M. O.

AU - van der Lely, A. J.

AU - van der Ploeg, L. H. T.

AU - Zigman, J. M.

AU - Kojima, M.

AU - Kangawa, K.

AU - Smith, R. G.

AU - Horvath, T.

AU - Tschoep, M. H.

PY - 2015/6

Y1 - 2015/6

N2 - BackgroundThe gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.Scope of reviewIn this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.Major conclusionsIn recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

AB - BackgroundThe gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.Scope of reviewIn this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.Major conclusionsIn recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

KW - Ghrelin

KW - Growth hormone segretagogue receptor

U2 - 10.1016/j.molmet.2015.03.005

DO - 10.1016/j.molmet.2015.03.005

M3 - Review

C2 - 26042199

VL - 4

SP - 437

EP - 460

JO - Molecular Metabolism

JF - Molecular Metabolism

SN - 2212-8778

IS - 6

ER -