Abstract
| Original language | English |
|---|---|
| Article number | 1124 |
| Journal | Nature Communications |
| Volume | 10 |
| Issue number | 1 |
| Number of pages | 12 |
| ISSN | 2041-1723 |
| DOIs | |
| Publication status | Published - 2019 |
| Externally published | Yes |
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- Global monitoring of antimicrobial resistance basedon metagenomics analyses of urban sewageFinal published version, 3.86 MB
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Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. / Hendriksen, Rene S.; Munk, Patrick; Njage, Patrick; van Bunnik, Bram; McNally, Luke; Lukjancenko, Oksana; Röder, Timo; Nieuwenhuijse, David; Pedersen, Susanne Karlsmose; Kjeldgaard, Jette; Kaas, Rolf S.; Clausen, Philip Thomas Lanken Conradsen; Vogt, Josef Korbinian; Leekitcharoenphon, Pimlapas; van de Schans, Milou G.M.; Zuidema, Tina; de Roda Husman, Ana Maria; Rasmussen, Simon; Petersen, Bent; Bego, Artan; Rees, Catherine; Cassar, Susan; Coventry, Kris; Collignon, Peter; Allerberger, Franz; Rahube, Teddie O.; Oliveira, Guilherme; Ivanov, Ivan; Vuthy, Yith; Sopheak, Thet; Yost, Christopher K.; Ke, Changwen; Zheng, Huanying; Baisheng, Li; Jiao, Xiaoyang; Donado-Godoy, Pilar; Coulibaly, Kalpy Julien; Jergović, Matijana; Hrenovic, Jasna; Karpíšková, Renáta; Villacis, Jose Eduardo; Legesse, Mengistu; Eguale, Tadesse; Heikinheimo, Annamari; Malania, Lile; Nitsche, Andreas; Brinkmann, Annika; Saba, Courage Kosi Setsoafia; Kocsis, Bela; Solymosi, Norbert; Thorsteinsdottir, Thorunn R.; Hatha, Abdulla Mohamed; Alebouyeh, Masoud; Morris, Dearbhaile; Cormican, Martin; O’Connor, Louise; Moran-Gilad, Jacob; Alba, Patricia; Battisti, Antonio; Shakenova, Zeinegul; Kiiyukia, Ciira; Ng’eno, Eric; Raka, Lul; Avsejenko, Jeļena; Bērziņš, Aivars; Bartkevics, Vadims; Penny, Christian; Rajandas, Heraa; Parimannan, Sivachandran; Haber, Malcolm Vella; Pal, Pushkar; Jeunen, Gert Jan; Gemmell, Neil; Fashae, Kayode; Holmstad, Rune; Hasan, Rumina; Shakoor, Sadia; Rojas, Maria Luz Zamudio; Wasyl, Dariusz; Bosevska, Golubinka; Kochubovski, Mihail; Radu, Cojocaru; Gassama, Amy; Radosavljevic, Vladimir; Wuertz, Stefan; Zuniga-Montanez, Rogelio; Tay, Moon Y.F.; Gavačová, Dagmar; Pastuchova, Katarina; Truska, Peter; Trkov, Marija; Esterhuyse, Kerneels; Keddy, Karen; Cerdà-Cuéllar, Marta; Pathirage, Sujatha; Norrgren, Leif; Örn, Stefan; Larsson, D. G.Joakim; Heijden, Tanja Van der; Kumburu, Happiness Houka; Sanneh, Bakary; Bidjada, Pawou; Njanpop-Lafourcade, Berthe Marie; Nikiema-Pessinaba, Somtinda Christelle; Levent, Belkis; Meschke, John Scott; Beck, Nicola Koren; Van, Chinh Dang; Phuc, Nguyen Do; Tran, Doan Minh Nguyen; Kwenda, Geoffrey; Tabo, Djim adjim; Wester, Astrid Louise; Cuadros-Orellana, Sara; Amid, Clara; Cochrane, Guy; Sicheritz-Ponten, Thomas; Schmitt, Heike; Alvarez, Jorge Raul Matheu; Aidara-Kane, Awa; Pamp, Sünje J.; Lund, Ole; Hald, Tine; Woolhouse, Mark; Koopmans, Marion P.; Vigre, Håkan; Petersen, Thomas Nordahl; Aarestrup, Frank M.
In: Nature Communications, Vol. 10, No. 1, 1124, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
}
TY - JOUR
T1 - Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
AU - Hendriksen, Rene S.
AU - Munk, Patrick
AU - Njage, Patrick
AU - van Bunnik, Bram
AU - McNally, Luke
AU - Lukjancenko, Oksana
AU - Röder, Timo
AU - Nieuwenhuijse, David
AU - Pedersen, Susanne Karlsmose
AU - Kjeldgaard, Jette
AU - Kaas, Rolf S.
AU - Clausen, Philip Thomas Lanken Conradsen
AU - Vogt, Josef Korbinian
AU - Leekitcharoenphon, Pimlapas
AU - van de Schans, Milou G.M.
AU - Zuidema, Tina
AU - de Roda Husman, Ana Maria
AU - Rasmussen, Simon
AU - Petersen, Bent
AU - Bego, Artan
AU - Rees, Catherine
AU - Cassar, Susan
AU - Coventry, Kris
AU - Collignon, Peter
AU - Allerberger, Franz
AU - Rahube, Teddie O.
AU - Oliveira, Guilherme
AU - Ivanov, Ivan
AU - Vuthy, Yith
AU - Sopheak, Thet
AU - Yost, Christopher K.
AU - Ke, Changwen
AU - Zheng, Huanying
AU - Baisheng, Li
AU - Jiao, Xiaoyang
AU - Donado-Godoy, Pilar
AU - Coulibaly, Kalpy Julien
AU - Jergović, Matijana
AU - Hrenovic, Jasna
AU - Karpíšková, Renáta
AU - Villacis, Jose Eduardo
AU - Legesse, Mengistu
AU - Eguale, Tadesse
AU - Heikinheimo, Annamari
AU - Malania, Lile
AU - Nitsche, Andreas
AU - Brinkmann, Annika
AU - Saba, Courage Kosi Setsoafia
AU - Kocsis, Bela
AU - Solymosi, Norbert
AU - Thorsteinsdottir, Thorunn R.
AU - Hatha, Abdulla Mohamed
AU - Alebouyeh, Masoud
AU - Morris, Dearbhaile
AU - Cormican, Martin
AU - O’Connor, Louise
AU - Moran-Gilad, Jacob
AU - Alba, Patricia
AU - Battisti, Antonio
AU - Shakenova, Zeinegul
AU - Kiiyukia, Ciira
AU - Ng’eno, Eric
AU - Raka, Lul
AU - Avsejenko, Jeļena
AU - Bērziņš, Aivars
AU - Bartkevics, Vadims
AU - Penny, Christian
AU - Rajandas, Heraa
AU - Parimannan, Sivachandran
AU - Haber, Malcolm Vella
AU - Pal, Pushkar
AU - Jeunen, Gert Jan
AU - Gemmell, Neil
AU - Fashae, Kayode
AU - Holmstad, Rune
AU - Hasan, Rumina
AU - Shakoor, Sadia
AU - Rojas, Maria Luz Zamudio
AU - Wasyl, Dariusz
AU - Bosevska, Golubinka
AU - Kochubovski, Mihail
AU - Radu, Cojocaru
AU - Gassama, Amy
AU - Radosavljevic, Vladimir
AU - Wuertz, Stefan
AU - Zuniga-Montanez, Rogelio
AU - Tay, Moon Y.F.
AU - Gavačová, Dagmar
AU - Pastuchova, Katarina
AU - Truska, Peter
AU - Trkov, Marija
AU - Esterhuyse, Kerneels
AU - Keddy, Karen
AU - Cerdà-Cuéllar, Marta
AU - Pathirage, Sujatha
AU - Norrgren, Leif
AU - Örn, Stefan
AU - Larsson, D. G.Joakim
AU - Heijden, Tanja Van der
AU - Kumburu, Happiness Houka
AU - Sanneh, Bakary
AU - Bidjada, Pawou
AU - Njanpop-Lafourcade, Berthe Marie
AU - Nikiema-Pessinaba, Somtinda Christelle
AU - Levent, Belkis
AU - Meschke, John Scott
AU - Beck, Nicola Koren
AU - Van, Chinh Dang
AU - Phuc, Nguyen Do
AU - Tran, Doan Minh Nguyen
AU - Kwenda, Geoffrey
AU - Tabo, Djim adjim
AU - Wester, Astrid Louise
AU - Cuadros-Orellana, Sara
AU - Amid, Clara
AU - Cochrane, Guy
AU - Sicheritz-Ponten, Thomas
AU - Schmitt, Heike
AU - Alvarez, Jorge Raul Matheu
AU - Aidara-Kane, Awa
AU - Pamp, Sünje J.
AU - Lund, Ole
AU - Hald, Tine
AU - Woolhouse, Mark
AU - Koopmans, Marion P.
AU - Vigre, Håkan
AU - Petersen, Thomas Nordahl
AU - Aarestrup, Frank M.
PY - 2019
Y1 - 2019
N2 - Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
AB - Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.
U2 - 10.1038/s41467-019-08853-3
DO - 10.1038/s41467-019-08853-3
M3 - Journal article
C2 - 30850636
VL - 10
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 1124
ER -