Glucose metabolism in small subcortical structures in Parkinson's disease

Per Borghammer; Søren B Hansen; Carsten Eggers; Mallar Chakravarty; Kim Vang; Joel Aanerud; Rüdiger Hilker; Wolf-Dieter Heiss; Anders Rodell; Ole Lajord Munk; David Keator; Albert Gjedde

doi:10.1111/j.1600-0404.2011.01556.x

Glucose metabolism in small subcortical structures in Parkinson's disease

Per Borghammer, Søren B Hansen, Carsten Eggers, Mallar Chakravarty, Kim Vang, Joel Aanerud, Rüdiger Hilker, Wolf-Dieter Heiss, Anders Rodell, Ole Lajord Munk, David Keator, Albert Gjedde

Research output: Contribution to journal › Journal article › Research › peer-review

36 Citations (Scopus)

Abstract

Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei.

Original language	English
Journal	Acta Neurologica Scandinavica
Volume	125
Issue number	5
Pages (from-to)	303-10
Number of pages	8
ISSN	0001-6314
DOIs	https://doi.org/10.1111/j.1600-0404.2011.01556.x
Publication status	Published - May 2012

Keywords

Aged
Brain
Brain Diseases, Metabolic
Case-Control Studies
Female
Glucose
Humans
Male
Middle Aged
Parkinson Disease
Positron-Emission Tomography

Access to Document

10.1111/j.1600-0404.2011.01556.x

Cite this

@article{54ea90f82ced4aac8fa4f072cffe2c69,

title = "Glucose metabolism in small subcortical structures in Parkinson's disease",

abstract = "Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei.",

keywords = "Aged, Brain, Brain Diseases, Metabolic, Case-Control Studies, Female, Glucose, Humans, Male, Middle Aged, Parkinson Disease, Positron-Emission Tomography",

author = "Per Borghammer and Hansen, {S{\o}ren B} and Carsten Eggers and Mallar Chakravarty and Kim Vang and Joel Aanerud and R{\"u}diger Hilker and Wolf-Dieter Heiss and Anders Rodell and Munk, {Ole Lajord} and David Keator and Albert Gjedde",

note = "{\textcopyright} 2011 John Wiley & Sons A/S.",

year = "2012",

month = may,

doi = "10.1111/j.1600-0404.2011.01556.x",

language = "English",

volume = "125",

pages = "303--10",

journal = "Acta Neurologica Scandinavica",

issn = "0001-6314",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Glucose metabolism in small subcortical structures in Parkinson's disease

AU - Borghammer, Per

AU - Hansen, Søren B

AU - Eggers, Carsten

AU - Chakravarty, Mallar

AU - Vang, Kim

AU - Aanerud, Joel

AU - Hilker, Rüdiger

AU - Heiss, Wolf-Dieter

AU - Rodell, Anders

AU - Munk, Ole Lajord

AU - Keator, David

AU - Gjedde, Albert

PY - 2012/5

Y1 - 2012/5

N2 - Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei.

AB - Evidence from experimental animal models of Parkinson's disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei.

KW - Aged

KW - Brain

KW - Brain Diseases, Metabolic

KW - Case-Control Studies

KW - Female

KW - Glucose

KW - Humans

KW - Male

KW - Middle Aged

KW - Parkinson Disease

KW - Positron-Emission Tomography

U2 - 10.1111/j.1600-0404.2011.01556.x

DO - 10.1111/j.1600-0404.2011.01556.x

M3 - Journal article

C2 - 21692755

SN - 0001-6314

VL - 125

SP - 303

EP - 310

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 5

ER -