GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance

Ulla Kampmann; Britt Christensen; Thomas Svava Nielsen; Steen Bønløkke Pedersen; Lotte Ørskov; Sten Lund; Niels Møller; Niels Jessen

doi:10.1371/journal.pone.0027854

GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance

Ulla Kampmann, Britt Christensen, Thomas Svava Nielsen, Steen Bønløkke Pedersen, Lotte Ørskov, Sten Lund, Niels Møller, Niels Jessen

Research output: Contribution to journal › Journal article › Research › peer-review

75 Citations (Scopus)

Abstract

Subgroups of patients with type 2 diabetes mellitus demand large insulin doses to maintain euglycemia. These patients are characterized by severe skeletal muscle insulin resistance and the underlying pathology remains unclear. The purpose of this study was to examine protein expression of the principal glucose transporter, GLUT4, and associated proteins in skeletal muscle from type 2 diabetic patients characterized by severe insulin resistance.

Original language	English
Journal	PLOS ONE
Volume	6
Issue number	11
Pages (from-to)	e27854
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0027854
Publication status	Published - 2011
Externally published	Yes

Keywords

Blotting, Western
Case-Control Studies
Diabetes Mellitus, Type 2
Female
Glucose Transporter Type 4
Humans
Insulin Resistance
Male
Middle Aged
Muscle, Skeletal
RNA, Messenger
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Ubiquitin-Conjugating Enzymes

Access to Document

10.1371/journal.pone.0027854

Cite this

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title = "GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance",

abstract = "Subgroups of patients with type 2 diabetes mellitus demand large insulin doses to maintain euglycemia. These patients are characterized by severe skeletal muscle insulin resistance and the underlying pathology remains unclear. The purpose of this study was to examine protein expression of the principal glucose transporter, GLUT4, and associated proteins in skeletal muscle from type 2 diabetic patients characterized by severe insulin resistance.",

keywords = "Blotting, Western, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Glucose Transporter Type 4, Humans, Insulin Resistance, Male, Middle Aged, Muscle, Skeletal, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ubiquitin-Conjugating Enzymes",

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AU - Kampmann, Ulla

AU - Christensen, Britt

AU - Nielsen, Thomas Svava

AU - Pedersen, Steen Bønløkke

AU - Ørskov, Lotte

AU - Lund, Sten

AU - Møller, Niels

AU - Jessen, Niels

PY - 2011

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KW - Blotting, Western

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Glucose Transporter Type 4

KW - Humans

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - RNA, Messenger

KW - Real-Time Polymerase Chain Reaction

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Ubiquitin-Conjugating Enzymes

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