Glycine: a long-sought novel ligand for GPR158

Mette Marie Rosenkilde; Jesper Mosolff Mathiesen

doi:10.1016/j.tips.2023.05.004

Glycine: a long-sought novel ligand for GPR158

Mette Marie Rosenkilde^*, Jesper Mosolff Mathiesen

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Research › peer-review

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Abstract

G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

Original language	English
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	8
Pages (from-to)	489-491
ISSN	0165-6147
DOIs	https://doi.org/10.1016/j.tips.2023.05.004
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Keywords

class C GPCRs
glycine
GPR158
metabotropic receptor

Access to Document

10.1016/j.tips.2023.05.004

FulltextAccepted author manuscript, 217 KBLicence: CC BY-NC-ND

Cite this

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title = "Glycine: a long-sought novel ligand for GPR158",

abstract = "G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.",

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author = "Rosenkilde, {Mette Marie} and Mathiesen, {Jesper Mosolff}",

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year = "2023",

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T2 - a long-sought novel ligand for GPR158

AU - Rosenkilde, Mette Marie

AU - Mathiesen, Jesper Mosolff

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N2 - G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

AB - G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

KW - class C GPCRs

KW - glycine

KW - GPR158

KW - metabotropic receptor

U2 - 10.1016/j.tips.2023.05.004

DO - 10.1016/j.tips.2023.05.004

M3 - Letter

C2 - 37321907

AN - SCOPUS:85162846179

VL - 44

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JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

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