GPCRdb: an information system for G protein-coupled receptors

Vignir Isberg; Stefan Mordalski; Christian Munk; Krzysztof Rataj; Kasper Harpsøe; Alexander S Hauser; Bas Vroling; Andrzej J Bojarski; Gert Vriend; David E Gloriam

doi:10.1093/nar/gkv1178

GPCRdb: an information system for G protein-coupled receptors

Vignir Isberg, Stefan Mordalski, Christian Munk, Krzysztof Rataj, Kasper Harpsøe, Alexander S Hauser, Bas Vroling, Andrzej J Bojarski, Gert Vriend, David E Gloriam

Research output: Contribution to journal › Journal article › Research › peer-review

227 Citations (Scopus)

410 Downloads (Pure)

Abstract

Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.

Original language	English
Journal	Nucleic Acids Research
Volume	44
Issue number	D1
Pages (from-to)	D356-64
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gkv1178
Publication status	Published - 4 Jan 2016

Bibliographical note

FUNDING:
European Research Council [639125 to D.E.G]; Lundbeck
Foundation [R163-2013-16327 to D.E.G]; Danish Council
for Independent Research [1331-00180 to D.E.G]; Polish
National Science Centre [DEC-2014/12/T/NZ2/00529 to
S.M.]. Funding for open access charge: European Research
Council [639125 to D.E.G].

Keywords

Development of new medicine

Access to Document

10.1093/nar/gkv1178Licence: CC BY

Nucl. Acids Res.-2016-Isberg-D356-64Final published version, 2.59 MBLicence: CC BY

Cite this

GPCRdb : an information system for G protein-coupled receptors. / Isberg, Vignir; Mordalski, Stefan; Munk, Christian; Rataj, Krzysztof; Harpsøe, Kasper ; Hauser, Alexander S; Vroling, Bas; Bojarski, Andrzej J; Vriend, Gert; Gloriam, David E.

In: Nucleic Acids Research, Vol. 44, No. D1, 04.01.2016, p. D356-64.

Research output: Contribution to journal › Journal article › Research › peer-review

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