GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions

Gáspár Pándy-Szeker es; Luis P.Taracena Herrera; Jimmy Caroli; Ali A. Kermani; Yashraj Kulkarni; György M. Keseru; David E. Gloriam

doi:10.1093/nar/gkad1089

GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions

Gáspár Pándy-Szeker es, Luis P.Taracena Herrera, Jimmy Caroli, Ali A. Kermani, Yashraj Kulkarni, György M. Keseru, David E. Gloriam^*

^*Corresponding author for this work

Biopharmaceuticals

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

10 Downloads (Pure)

Abstract

G proteinsãre the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, tãstãntsãnd odorants. GproteinDb offers integrated genomic, str uct ural,ãnd pharmacological dataãnd tools forãnalysis, visualizationãnd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling dataãnd str uct ural templates,ãdding AlphaFold2 str uct ure models of GPCR-G protein comple x esãndãdvãncing the interactiv eãnaly sis tools f or their interfãces underlying coupling selectivity. We present insights on couplingãgreementãcross datasetsãnd parameters, including constitutiveãctivity,ãgonist-inducedãctivityãnd kinetics. GproteinDb isãccessibleãt https://gproteindb.org .

Original language	English
Journal	Nucleic Acids Research
Volume	52
Issue number	D1
Pages (from-to)	D466-D475
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gkad1089
Publication status	Published - 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2023.

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10.1093/nar/gkad1089

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Cite this

GproteinDb in 2024 : new G protein-GPCR couplings, AlphaFold2-multimer modelsãnd interface interactions. / Pándy-Szeker es, Gáspár; Herrera, Luis P.Taracena; Caroli, Jimmy; Kermani, Ali A.; Kulkarni, Yashraj; Keseru, György M.; Gloriam, David E.

In: Nucleic Acids Research, Vol. 52, No. D1, 2024, p. D466-D475.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "G proteins{\~a}re the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, t{\~a}st{\~a}nts{\~a}nd odorants. GproteinDb offers integrated genomic, str uct ural,{\~a}nd pharmacological data{\~a}nd tools for{\~a}nalysis, visualization{\~a}nd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling data{\~a}nd str uct ural templates,{\~a}dding AlphaFold2 str uct ure models of GPCR-G protein comple x es{\~a}nd{\~a}dv{\~a}ncing the interactiv e{\~a}naly sis tools f or their interf{\~a}ces underlying coupling selectivity. We present insights on coupling{\~a}greement{\~a}cross datasets{\~a}nd parameters, including constitutive{\~a}ctivity,{\~a}gonist-induced{\~a}ctivity{\~a}nd kinetics. GproteinDb is{\~a}ccessible{\~a}t https://gproteindb.org . ",

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AU - Caroli, Jimmy

AU - Kermani, Ali A.

AU - Kulkarni, Yashraj

AU - Keseru, György M.

AU - Gloriam, David E.

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AB - G proteinsãre the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, tãstãntsãnd odorants. GproteinDb offers integrated genomic, str uct ural,ãnd pharmacological dataãnd tools forãnalysis, visualizationãnd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling dataãnd str uct ural templates,ãdding AlphaFold2 str uct ure models of GPCR-G protein comple x esãndãdvãncing the interactiv eãnaly sis tools f or their interfãces underlying coupling selectivity. We present insights on couplingãgreementãcross datasetsãnd parameters, including constitutiveãctivity,ãgonist-inducedãctivityãnd kinetics. GproteinDb isãccessibleãt https://gproteindb.org .

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