TY - JOUR
T1 - Gut microbiome development along the colorectal adenoma-carcinoma sequence
AU - Feng, Qiang
AU - Liang, Suisha
AU - Jia, Huijue
AU - Stadlmayr, Andreas
AU - Tang, Longqing
AU - Lan, Zhou
AU - Zhang, Dongya
AU - Xia, Huihua
AU - Xu, Xiaoying
AU - Jie, Zhuye
AU - Su, Lili
AU - Li, Xiaoping
AU - Li, Xin
AU - Li, Junhua
AU - Xiao, Liang
AU - Huber-Schönauer, Ursula
AU - Niederseer, David
AU - Xu, Xun
AU - Al-Aama, Jumana Yousuf
AU - Yang, Huanming
AU - Wang, Jian
AU - Kristiansen, Karsten
AU - Arumugam, Manimozhiyan
AU - Tilg, Herbert
AU - Datz, Christian
AU - Wang, Jun
PY - 2015
Y1 - 2015
N2 - Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.
AB - Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.
U2 - 10.1038/ncomms7528
DO - 10.1038/ncomms7528
M3 - Journal article
C2 - 25758642
VL - 6
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 6528
ER -