Abstract
| Original language | English |
|---|---|
| Journal | Nature Genetics |
| Volume | 45 |
| Issue number | 4 |
| Pages (from-to) | 362-70, 370e1-2 |
| Number of pages | 11 |
| ISSN | 1061-4036 |
| DOIs | |
| Publication status | Published - Apr 2013 |
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GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. / Pharoah, Paul D P; Tsai, Ya-Yu; Ramus, Susan J; Phelan, Catherine M; Goode, Ellen L; Lawrenson, Kate; Buckley, Melissa; Fridley, Brooke L; Tyrer, Jonathan P; Shen, Howard; Weber, Rachel; Karevan, Rod; Larson, Melissa C; Song, Honglin; Tessier, Daniel C; Bacot, François; Vincent, Daniel; Cunningham, Julie M; Dennis, Joe; Dicks, Ed; Aben, Katja K; Anton-Culver, Hoda; Antonenkova, Natalia; Armasu, Sebastian M; Baglietto, Laura; Bandera, Elisa V; Beckmann, Matthias W; Birrer, Michael J; Bloom, Greg; Bogdanova, Natalia; Brenton, James D; Brinton, Louise A; Brooks-Wilson, Angela; Brown, Robert James (Jim); Butzow, Ralf; Campbell, Ian; Carney, Michael E; Carvalho, Renato S; Chang-Claude, Jenny; Chen, Y Anne; Chen, Zhihua; Chow, Wong-Ho; Cicek, Mine S; Coetzee, Gerhard; Cook, Linda S; Cramer, Daniel W; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; Despierre, Evelyn; Doherty, Jennifer A; Dörk, Thilo; du Bois, Andreas; Dürst, Matthias; Eccles, Diana; Edwards, Robert; Ekici, Arif B; Fasching, Peter A; Fenstermacher, David; Flanagan, James; Gao, Yu-Tang; Garcia-Closas, Montserrat; Gentry-Maharaj, Aleksandra; Giles, Graham; Gjyshi, Anxhela; Gore, Martin; Gronwald, Jacek; Guo, Qi; Halle, Mari K; Harter, Philipp; Hein, Alexander; Heitz, Florian; Hillemanns, Peter; Hoatlin, Maureen; Høgdall, Estrid; Høgdall, Claus K; Hosono, Satoyo; Jakubowska, Anna; Jensen, Allan; Kalli, Kimberly R; Karlan, Beth Y; Kelemen, Linda E; Kiemeney, Lambertus A; Kjaer, Susanne Krüger; Konecny, Gottfried E; Krakstad, Camilla; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D; Lee, Nathan; Lee, Janet; Leminen, Arto; Lim, Boon Kiong; Lissowska, Jolanta; Lubi?ski, Jan; Lundvall, Lene; Lurie, Galina; Massuger, Leon F A G; Matsuo, Keitaro; McGuire, Valerie; McLaughlin, John R; Menon, Usha; Modugno, Francesmary; Moysich, Kirsten B; Nakanishi, Toru; Narod, Steven A; Ness, Roberta B; Nevanlinna, Heli; Nickels, Stefan; Noushmehr, Houtan; Odunsi, Kunle; Olson, Sara; Orlow, Irene; Paul, James; Pejovic, Tanja; Pelttari, Liisa M; Permuth-Wey, Jenny; Pike, Malcolm C; Poole, Elizabeth M; Qu, Xiaotao; Risch, Harvey A; Rodriguez-Rodriguez, Lorna; Rossing, Mary Anne; Rudolph, Anja; Runnebaum, Ingo; Rzepecka, Iwona K; Salvesen, Helga B; Schwaab, Ira; Severi, Gianluca; Shen, Hui; Shridhar, Vijayalakshmi; Shu, Xiao-Ou; Sieh, Weiva; Southey, Melissa C; Spellman, Paul; Tajima, Kazuo; Teo, Soo-Hwang; Terry, Kathryn L; Thompson, Pamela J; Timorek, Agnieszka; Tworoger, Shelley S; van Altena, Anne M; van den Berg, David; Vergote, Ignace; Vierkant, Robert A; Vitonis, Allison F; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S; Wik, Elisabeth; Winterhoff, Boris; Woo, Yin Ling; Wu, Anna H; Yang, Hannah P; Zheng, Wei; Ziogas, Argyrios; Zulkifli, Famida; Goodman, Marc T; Hall, Per; Easton, Douglas F; Pearce, Celeste L; Berchuck, Andrew; Chenevix-Trench, Georgia; Iversen, Edwin; Monteiro, Alvaro N A; Gayther, Simon A; Schildkraut, Joellen M; Sellers, Thomas A; Study, Australian Cancer.
In: Nature Genetics, Vol. 45, No. 4, 04.2013, p. 362-70, 370e1-2.Research output: Contribution to journal › Journal article › Research › peer-review
}
TY - JOUR
T1 - GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
AU - Pharoah, Paul D P
AU - Tsai, Ya-Yu
AU - Ramus, Susan J
AU - Phelan, Catherine M
AU - Goode, Ellen L
AU - Lawrenson, Kate
AU - Buckley, Melissa
AU - Fridley, Brooke L
AU - Tyrer, Jonathan P
AU - Shen, Howard
AU - Weber, Rachel
AU - Karevan, Rod
AU - Larson, Melissa C
AU - Song, Honglin
AU - Tessier, Daniel C
AU - Bacot, François
AU - Vincent, Daniel
AU - Cunningham, Julie M
AU - Dennis, Joe
AU - Dicks, Ed
AU - Aben, Katja K
AU - Anton-Culver, Hoda
AU - Antonenkova, Natalia
AU - Armasu, Sebastian M
AU - Baglietto, Laura
AU - Bandera, Elisa V
AU - Beckmann, Matthias W
AU - Birrer, Michael J
AU - Bloom, Greg
AU - Bogdanova, Natalia
AU - Brenton, James D
AU - Brinton, Louise A
AU - Brooks-Wilson, Angela
AU - Brown, Robert James (Jim)
AU - Butzow, Ralf
AU - Campbell, Ian
AU - Carney, Michael E
AU - Carvalho, Renato S
AU - Chang-Claude, Jenny
AU - Chen, Y Anne
AU - Chen, Zhihua
AU - Chow, Wong-Ho
AU - Cicek, Mine S
AU - Coetzee, Gerhard
AU - Cook, Linda S
AU - Cramer, Daniel W
AU - Cybulski, Cezary
AU - Dansonka-Mieszkowska, Agnieszka
AU - Despierre, Evelyn
AU - Doherty, Jennifer A
AU - Dörk, Thilo
AU - du Bois, Andreas
AU - Dürst, Matthias
AU - Eccles, Diana
AU - Edwards, Robert
AU - Ekici, Arif B
AU - Fasching, Peter A
AU - Fenstermacher, David
AU - Flanagan, James
AU - Gao, Yu-Tang
AU - Garcia-Closas, Montserrat
AU - Gentry-Maharaj, Aleksandra
AU - Giles, Graham
AU - Gjyshi, Anxhela
AU - Gore, Martin
AU - Gronwald, Jacek
AU - Guo, Qi
AU - Halle, Mari K
AU - Harter, Philipp
AU - Hein, Alexander
AU - Heitz, Florian
AU - Hillemanns, Peter
AU - Hoatlin, Maureen
AU - Høgdall, Estrid
AU - Høgdall, Claus K
AU - Hosono, Satoyo
AU - Jakubowska, Anna
AU - Jensen, Allan
AU - Kalli, Kimberly R
AU - Karlan, Beth Y
AU - Kelemen, Linda E
AU - Kiemeney, Lambertus A
AU - Kjaer, Susanne Krüger
AU - Konecny, Gottfried E
AU - Krakstad, Camilla
AU - Kupryjanczyk, Jolanta
AU - Lambrechts, Diether
AU - Lambrechts, Sandrina
AU - Le, Nhu D
AU - Lee, Nathan
AU - Lee, Janet
AU - Leminen, Arto
AU - Lim, Boon Kiong
AU - Lissowska, Jolanta
AU - Lubi?ski, Jan
AU - Lundvall, Lene
AU - Lurie, Galina
AU - Massuger, Leon F A G
AU - Matsuo, Keitaro
AU - McGuire, Valerie
AU - McLaughlin, John R
AU - Menon, Usha
AU - Modugno, Francesmary
AU - Moysich, Kirsten B
AU - Nakanishi, Toru
AU - Narod, Steven A
AU - Ness, Roberta B
AU - Nevanlinna, Heli
AU - Nickels, Stefan
AU - Noushmehr, Houtan
AU - Odunsi, Kunle
AU - Olson, Sara
AU - Orlow, Irene
AU - Paul, James
AU - Pejovic, Tanja
AU - Pelttari, Liisa M
AU - Permuth-Wey, Jenny
AU - Pike, Malcolm C
AU - Poole, Elizabeth M
AU - Qu, Xiaotao
AU - Risch, Harvey A
AU - Rodriguez-Rodriguez, Lorna
AU - Rossing, Mary Anne
AU - Rudolph, Anja
AU - Runnebaum, Ingo
AU - Rzepecka, Iwona K
AU - Salvesen, Helga B
AU - Schwaab, Ira
AU - Severi, Gianluca
AU - Shen, Hui
AU - Shridhar, Vijayalakshmi
AU - Shu, Xiao-Ou
AU - Sieh, Weiva
AU - Southey, Melissa C
AU - Spellman, Paul
AU - Tajima, Kazuo
AU - Teo, Soo-Hwang
AU - Terry, Kathryn L
AU - Thompson, Pamela J
AU - Timorek, Agnieszka
AU - Tworoger, Shelley S
AU - van Altena, Anne M
AU - van den Berg, David
AU - Vergote, Ignace
AU - Vierkant, Robert A
AU - Vitonis, Allison F
AU - Wang-Gohrke, Shan
AU - Wentzensen, Nicolas
AU - Whittemore, Alice S
AU - Wik, Elisabeth
AU - Winterhoff, Boris
AU - Woo, Yin Ling
AU - Wu, Anna H
AU - Yang, Hannah P
AU - Zheng, Wei
AU - Ziogas, Argyrios
AU - Zulkifli, Famida
AU - Goodman, Marc T
AU - Hall, Per
AU - Easton, Douglas F
AU - Pearce, Celeste L
AU - Berchuck, Andrew
AU - Chenevix-Trench, Georgia
AU - Iversen, Edwin
AU - Monteiro, Alvaro N A
AU - Gayther, Simon A
AU - Schildkraut, Joellen M
AU - Sellers, Thomas A
AU - Study, Australian Cancer
PY - 2013/4
Y1 - 2013/4
N2 - Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10−9) and 10p12 (rs1243180, P = 1.8 × 10−8) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10−10). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
AB - Genome-wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the UK. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. We performed follow-up genotyping in 18,174 individuals with EOC (cases) and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10−9) and 10p12 (rs1243180, P = 1.8 × 10−8) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10−10). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer.
U2 - 10.1038/ng.2564
DO - 10.1038/ng.2564
M3 - Journal article
VL - 45
SP - 362-70, 370e1-2
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -