Harnessing transcription for bioproduction in cyanobacteria

Karin Stensjö; Konstantinos Vavitsas; Taina Tyystjärvi

doi:10.1111/ppl.12606

Harnessing transcription for bioproduction in cyanobacteria

Karin Stensjö
, Konstantinos Vavitsas
, Taina Tyystjärvi

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Sustainable production of biofuels and other valuable compounds is one of our future challenges. One tempting possibility is to use photosynthetic cyanobacteria as production factories. Currently, tools for genetic engineering of cyanobacteria are yet not good enough to exploit the full potential of cyanobacteria. A wide variety of expression systems will be required to adjust both the expression of heterologous enzyme(s) and metabolic routes to the best possible balance, allowing the optimal production of a particular substance. In bacteria, transcription, especially the initiation of transcription, has a central role in adjusting gene expression and thus also metabolic fluxes of cells according to environmental cues. Here we summarize the recent progress in developing tools for efficient cyanofactories, focusing especially on transcriptional regulation.

Original language	English
Journal	Physiologia Plantarum
Volume	162
Issue number	2
Pages (from-to)	148-155
Number of pages	8
ISSN	0031-9317
DOIs	https://doi.org/10.1111/ppl.12606
Publication status	Published - 1 Feb 2018

Bibliographical note

Special Issue: 70 years of SPPS – Outlook by Early‐Career PIs

Funding

Acknowledgements – We thank Xin Li for helping with figure preparation and Adam Wegelius for valuable comments. The Swedish Energy Agency and K.A Wallenberg Foundation (K. S.), Copenhagen Plant Science Centre and Innovation Fund Denmark, project 12–131834 (K. V.) and The Academy of Finland, grant no. 265807 (T. T.) are acknowledged for financial support.

Keywords

Journal Article

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Cite this

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