Abstract
Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Investigation |
| Volume | 36 |
| Issue number | 2 |
| Pages (from-to) | 69-75 |
| Number of pages | 7 |
| ISSN | 0014-2972 |
| DOIs | |
| Publication status | Published - Feb 2006 |
Keywords
- Animals
- Atrial Natriuretic Factor
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 1
- Guanylate Cyclase
- Heart
- Male
- Mice
- Mice, Inbred C57BL
- Natriuretic Peptide, Brain
- Natriuretic Peptide, C-Type
- Natriuretic Peptides
- RNA, Messenger
- Receptors, Atrial Natriuretic Factor
- Up-Regulation