High glucose impairs superoxide production from isolated blood neutrophils

A Perner; S E Nielsen; J Rask-Madsen

doi:10.1007/s00134-002-1628-4

High glucose impairs superoxide production from isolated blood neutrophils

A Perner, S E Nielsen, J Rask-Madsen

Research output: Contribution to journal › Journal article › Research › peer-review

148 Citations (Scopus)

Abstract

Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.

Original language	English
Journal	Intensive Care Medicine
Volume	29
Issue number	4
Pages (from-to)	642-5
Number of pages	4
ISSN	0342-4642
DOIs	https://doi.org/10.1007/s00134-002-1628-4
Publication status	Published - Apr 2003

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10.1007/s00134-002-1628-4

Cite this

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title = "High glucose impairs superoxide production from isolated blood neutrophils",

abstract = "Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.",

author = "A Perner and Nielsen, {S E} and J Rask-Madsen",

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doi = "10.1007/s00134-002-1628-4",

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T1 - High glucose impairs superoxide production from isolated blood neutrophils

AU - Perner, A

AU - Nielsen, S E

AU - Rask-Madsen, J

PY - 2003/4

Y1 - 2003/4

N2 - Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.

AB - Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.

U2 - 10.1007/s00134-002-1628-4

DO - 10.1007/s00134-002-1628-4

M3 - Journal article

SN - 0342-4642

VL - 29

SP - 642

EP - 645

JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 4

ER -