High-grade cervical lesions after vaccination against human papillomavirus: A Danish cohort study

Lise Holst Thamsborg; George Napolitano; Lise Grupe Larsen; Elsebeth Lynge

doi:10.1111/aogs.13935

High-grade cervical lesions after vaccination against human papillomavirus: A Danish cohort study

Lise Holst Thamsborg^*, George Napolitano, Lise Grupe Larsen, Elsebeth Lynge

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Introduction It is pertinent to evaluate the impact of vaccination against human papillomavirus (HPV) in real life. The aim of the study was to evaluate the real-life impact of HPV vaccination in the first birth cohort of Danish women offered free HPV vaccination as girls and invited to screening at the age of 23 years. Material and methods Women born in 1993 were offered free HPV vaccination at the age of 15 years but women born in 1983 have never been offered free HPV vaccination. We followed these two birth cohorts for 10 years from the age of 15 to after their first invitation to screening, and compared the risk of high-grade cervical intraepithelial neoplasia (CIN). Data were obtained from Danish national health registers. Results Vaccination coverage was 91% in the 1993 birth cohort and

Original language	English
Journal	Acta Obstetrica et Gynecologica
Volume	99
Issue number	10
Pages (from-to)	1290-1296
Number of pages	7
ISSN	0001-6349
DOIs	https://doi.org/10.1111/aogs.13935
Publication status	Published - 2020

Keywords

cervical intraepithelial neoplasia
early detection of cancer
human papillomavirus
prevention and control
vaccination
CYTOLOGY
THINPREP
SUREPATH
IMPACT
YOUNG
AGE

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10.1111/aogs.13935Licence: CC BY

High-grade cervical lesions after vaccination against human papillomavirusFinal published version, 567 KBLicence: CC BY

Cite this

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title = "High-grade cervical lesions after vaccination against human papillomavirus: A Danish cohort study",

abstract = "Introduction It is pertinent to evaluate the impact of vaccination against human papillomavirus (HPV) in real life. The aim of the study was to evaluate the real-life impact of HPV vaccination in the first birth cohort of Danish women offered free HPV vaccination as girls and invited to screening at the age of 23 years. Material and methods Women born in 1993 were offered free HPV vaccination at the age of 15 years but women born in 1983 have never been offered free HPV vaccination. We followed these two birth cohorts for 10 years from the age of 15 to after their first invitation to screening, and compared the risk of high-grade cervical intraepithelial neoplasia (CIN). Data were obtained from Danish national health registers. Results Vaccination coverage was 91% in the 1993 birth cohort and",

keywords = "cervical intraepithelial neoplasia, early detection of cancer, human papillomavirus, prevention and control, vaccination, CYTOLOGY, THINPREP, SUREPATH, IMPACT, YOUNG, AGE",

author = "Thamsborg, {Lise Holst} and George Napolitano and Larsen, {Lise Grupe} and Elsebeth Lynge",

year = "2020",

doi = "10.1111/aogs.13935",

language = "English",

volume = "99",

pages = "1290--1296",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

issn = "0001-6349",

publisher = "JohnWiley & Sons Ltd",

number = "10",

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TY - JOUR

T1 - High-grade cervical lesions after vaccination against human papillomavirus

T2 - A Danish cohort study

AU - Thamsborg, Lise Holst

AU - Napolitano, George

AU - Larsen, Lise Grupe

AU - Lynge, Elsebeth

PY - 2020

Y1 - 2020

N2 - Introduction It is pertinent to evaluate the impact of vaccination against human papillomavirus (HPV) in real life. The aim of the study was to evaluate the real-life impact of HPV vaccination in the first birth cohort of Danish women offered free HPV vaccination as girls and invited to screening at the age of 23 years. Material and methods Women born in 1993 were offered free HPV vaccination at the age of 15 years but women born in 1983 have never been offered free HPV vaccination. We followed these two birth cohorts for 10 years from the age of 15 to after their first invitation to screening, and compared the risk of high-grade cervical intraepithelial neoplasia (CIN). Data were obtained from Danish national health registers. Results Vaccination coverage was 91% in the 1993 birth cohort and

AB - Introduction It is pertinent to evaluate the impact of vaccination against human papillomavirus (HPV) in real life. The aim of the study was to evaluate the real-life impact of HPV vaccination in the first birth cohort of Danish women offered free HPV vaccination as girls and invited to screening at the age of 23 years. Material and methods Women born in 1993 were offered free HPV vaccination at the age of 15 years but women born in 1983 have never been offered free HPV vaccination. We followed these two birth cohorts for 10 years from the age of 15 to after their first invitation to screening, and compared the risk of high-grade cervical intraepithelial neoplasia (CIN). Data were obtained from Danish national health registers. Results Vaccination coverage was 91% in the 1993 birth cohort and

KW - cervical intraepithelial neoplasia

KW - early detection of cancer

KW - human papillomavirus

KW - prevention and control

KW - vaccination

KW - CYTOLOGY

KW - THINPREP

KW - SUREPATH

KW - IMPACT

KW - YOUNG

KW - AGE

U2 - 10.1111/aogs.13935

DO - 10.1111/aogs.13935

M3 - Journal article

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