High-resolution transcription atlas of the mitotic cell cycle in budding yeast

Marina V Granovskaia, Lars J Jensen, Matthew E Ritchie, Joern Toedling, Ye Ning, Peer Bork, Wolfgang Huber, Lars M Steinmetz

Research output: Contribution to journalJournal articleResearchpeer-review

90 Citations (Scopus)

Abstract

Extensive transcription of non-coding RNAs has been detected in eukaryotic genomes and is thought to constitute an additional layer in the regulation of gene expression. Despite this role, their transcription through the cell cycle has not been studied; genome-wide approaches have only focused on protein-coding genes. To explore the complex transcriptome architecture underlying the budding yeast cell cycle, we used 8 bp tiling arrays to generate a 5 minute-resolution, strand-specific expression atlas of the whole genome.
Original languageEnglish
JournalGenome Biology (Online Edition)
Volume11
Issue number3
Pages (from-to)R24
ISSN1474-7596
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Gene Expression Profiling
  • Gene Expression Regulation, Fungal
  • Genome, Fungal
  • Genomics
  • Mitosis
  • RNA, Antisense
  • RNA, Untranslated
  • Saccharomyces cerevisiae

Cite this