Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

Morten Skøtt Thomsen; Annelies Weyn; Jens D Mikkelsen

doi:10.1111/j.1399-5618.2011.00961.x

Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

Morten Skøtt Thomsen, Annelies Weyn, Jens D Mikkelsen

Research output: Contribution to journal › Journal article › Research

38 Citations (Scopus)

Abstract

The α7 nicotinic acetylcholine receptor (nAChR) is involved in cognitive function and synaptic plasticity. Consequently, changes in α7 nAChR function have been implicated in a variety of mental disorders, especially schizophrenia. However, there is little knowledge regarding the levels of the α7 nAChR in patients with bipolar disorder.

Original language	English
Journal	Bipolar Disorders (English Edition, Online)
Volume	13
Issue number	7-8
Pages (from-to)	701-7
Number of pages	7
ISSN	1399-5618
DOIs	https://doi.org/10.1111/j.1399-5618.2011.00961.x
Publication status	Published - 2011

Keywords

Adult
Analysis of Variance
Autoradiography
Bipolar Disorder
Bungarotoxins
Depressive Disorder, Major
Female
Gene Expression Regulation
Hippocampus
Humans
Iodine Isotopes
Male
Middle Aged
Protein Binding
Receptors, Nicotinic
Schizophrenia
alpha7 Nicotinic Acetylcholine Receptor

Access to Document

10.1111/j.1399-5618.2011.00961.x

Cite this

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title = "Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder",

abstract = "The α7 nicotinic acetylcholine receptor (nAChR) is involved in cognitive function and synaptic plasticity. Consequently, changes in α7 nAChR function have been implicated in a variety of mental disorders, especially schizophrenia. However, there is little knowledge regarding the levels of the α7 nAChR in patients with bipolar disorder.",

keywords = "Adult, Analysis of Variance, Autoradiography, Bipolar Disorder, Bungarotoxins, Depressive Disorder, Major, Female, Gene Expression Regulation, Hippocampus, Humans, Iodine Isotopes, Male, Middle Aged, Protein Binding, Receptors, Nicotinic, Schizophrenia, alpha7 Nicotinic Acetylcholine Receptor",

author = "Thomsen, {Morten Sk{\o}tt} and Annelies Weyn and Mikkelsen, {Jens D}",

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year = "2011",

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language = "English",

volume = "13",

pages = "701--7",

journal = "Bipolar Disorders (English Edition, Online)",

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T1 - Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

AU - Thomsen, Morten Skøtt

AU - Weyn, Annelies

AU - Mikkelsen, Jens D

PY - 2011

Y1 - 2011

N2 - The α7 nicotinic acetylcholine receptor (nAChR) is involved in cognitive function and synaptic plasticity. Consequently, changes in α7 nAChR function have been implicated in a variety of mental disorders, especially schizophrenia. However, there is little knowledge regarding the levels of the α7 nAChR in patients with bipolar disorder.

AB - The α7 nicotinic acetylcholine receptor (nAChR) is involved in cognitive function and synaptic plasticity. Consequently, changes in α7 nAChR function have been implicated in a variety of mental disorders, especially schizophrenia. However, there is little knowledge regarding the levels of the α7 nAChR in patients with bipolar disorder.

KW - Adult

KW - Analysis of Variance

KW - Autoradiography

KW - Bipolar Disorder

KW - Bungarotoxins

KW - Depressive Disorder, Major

KW - Female

KW - Gene Expression Regulation

KW - Hippocampus

KW - Humans

KW - Iodine Isotopes

KW - Male

KW - Middle Aged

KW - Protein Binding

KW - Receptors, Nicotinic

KW - Schizophrenia

KW - alpha7 Nicotinic Acetylcholine Receptor

U2 - 10.1111/j.1399-5618.2011.00961.x

DO - 10.1111/j.1399-5618.2011.00961.x

M3 - Journal article

C2 - 22085484

VL - 13

SP - 701

EP - 707

JO - Bipolar Disorders (English Edition, Online)

JF - Bipolar Disorders (English Edition, Online)

SN - 1399-5618

IS - 7-8

ER -