Hjertepåvirkning fra 5-fluorouracil og capecitabin

Translated title of the contribution: [Cardiotoxicity induced by 5-fluorouracil or capecitabine]

Søren Astrup Jensen, Lene Bæksgaard Jensen, Lone Nørgaard Petersen, Lars Reiter, Jens Benn Sørensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arrhythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.
Translated title of the contribution[Cardiotoxicity induced by 5-fluorouracil or capecitabine]
Original languageDanish
JournalUgeskrift for Laeger
Volume172
Issue number1
Pages (from-to)48-51
Number of pages4
ISSN0041-5782
Publication statusPublished - 4 Jan 2010

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