Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

S S Torekov, L Ma, N Grarup, B Hartmann, I A Hainerová, U Kielgast, H Kissow, M Rosenkilde, J Lebl, D R Witte, T Jørgensen, A Sandbaek, T Lauritzen, O D Madsen, J Wang, A Linneberg, S Madsbad, J J Holst, T Hansen, O PedersenGIANT Consortium

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Abstract

The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits.
Original languageEnglish
JournalDiabetologia
Volume54
Issue number11
Pages (from-to)2820-31
Number of pages12
ISSN0012-186X
DOIs
Publication statusPublished - 2011

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