TY - JOUR
T1 - Housing temperature influences exercise training adaptations in mice
AU - Raun, Steffen Henning
AU - Henriquez-Olguín, Carlos
AU - Karavaeva, Iuliia
AU - Ali, Mona
AU - Møller, Lisbeth Liliendal Valbjørn
AU - Kot, Witold
AU - Castro-Mejía, Josué Leonardo
AU - Nielsen, Dennis Sandris
AU - Gerhart-Hines, Zachary
AU - Richter, Erik A.
AU - Sylow, Lykke
N1 - CURIS 2020 NEXS 104
PY - 2020
Y1 - 2020
N2 - Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.
AB - Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used to investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation to humans. Thermoneutral housing is a strategy to make mice more metabolically similar to humans but its effects on exercise adaptations are unknown. Here we show that thermoneutral housing blunts exercise-induced improvements in insulin action in muscle and adipose tissue and reduces the effects of training on energy expenditure, body composition, and muscle and adipose tissue protein expressions. Thus, many reported effects of exercise training in mice are likely secondary to metabolic stress of ambient housing temperature, making it challenging to translate to humans. We conclude that adaptations to exercise training in mice critically depend upon housing temperature. Our findings underscore housing temperature as a critical parameter in the design and interpretation of murine exercise training studies.
U2 - 10.1038/s41467-020-15311-y
DO - 10.1038/s41467-020-15311-y
M3 - Journal article
C2 - 32214091
VL - 11
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 1560
ER -