TY - JOUR
T1 - How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology
AU - Yang, Zhenhua
AU - Rosenthal, Mariana
AU - Rosenberg, Noah A
AU - Talarico, Sarah
AU - Zhang, Lixin
AU - Marrs, Carl
AU - Thomsen, Vibeke Østergaard
AU - Lillebaek, Troels
AU - Andersen, Åse Bengård
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011/2/18
Y1 - 2011/2/18
N2 - Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.
AB - Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.
U2 - 10.1016/j.meegid.2011.02.002
DO - 10.1016/j.meegid.2011.02.002
M3 - Journal article
C2 - 21315848
VL - 11
SP - 1164
EP - 1167
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
SN - 1567-1348
IS - 5
ER -