@article{0b029ba66f6b4bcdaaf07500390025ff,
title = "Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine",
abstract = "Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is a widely used biomarker of oxidative stress. However, variability between chromatographic and ELISA methods hampers interpretation of data, and this variability may increase should urine composition differ between individuals, leading to assay interference. Furthermore, optimal urine sampling conditions are not well defined. We performed inter-laboratory comparisons of 8-oxodG measurement between mass spectrometric-, electrochemical- and ELISA-based methods, using common within-technique calibrants to analyze 8-oxodG-spiked phosphate-buffered saline and urine samples. We also investigated human subject- and sample collection-related variables, as potential sources of variability.",
keywords = "Adult, Artifacts, Buffers, Deoxyguanosine, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Reference Standards, Reproducibility of Results, Sodium Chloride, Solutions, Urinalysis, Young Adult",
author = "Lars Barregard and Peter M{\o}ller and Trine Henriksen and Vilas Mistry and Gudrun Koppen and Pavel Rossner and Sram, {Radim J} and Allan Weimann and Poulsen, {Henrik E} and Robert Nataf and Roberta Andreoli and Paola Manini and Tim Marczylo and Patricia Lam and Evans, {Mark D} and Hiroshi Kasai and Kazuaki Kawai and Yun-Shan Li and Kazuo Sakai and Rajinder Singh and Friederike Teichert and Farmer, {Peter B} and Rafal Rozalski and Daniel Gackowski and Agnieszka Siomek and Saez, {Guillermo T} and Concha Cerda and Karin Broberg and Christian Lindh and Hossain, {Mohammad Bakhtiar} and Siamak Haghdoost and Chiung-Wen Hu and Mu-Rong Chao and Kuen-Yuh Wu and Hilmi Orhan and Nilufer Senduran and Smith, {Raymond J} and Santella, {Regina M} and Yali Su and Czarina Cortez and Susan Yeh and Ryszard Olinski and Steffen Loft and Cooke, {Marcus S}",
year = "2013",
month = jun,
day = "20",
doi = "10.1089/ars.2012.4714",
language = "English",
volume = "18",
pages = "2377--91",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "18",
}