Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Guido Keijzers*, Daniela Bakula, Michael Angelo Petr, Nils Gedsig Kirkelund Madsen, Amanuel Teklu, Garik Mkrtchyan, Brenna Osborne, Morten Scheibye-Knudsen

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

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Abstract

Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

Original languageEnglish
Article number74
JournalInternational Journal of Molecular Sciences
Volume20
Issue number1
Number of pages15
ISSN1661-6596
DOIs
Publication statusPublished - 2019

Keywords

  • DNA repair
  • Double strand break repair
  • EXO1
  • Exonuclease 1
  • Mismatch repair
  • MMR
  • NER
  • Nucleotide excision repair
  • Strand displacements
  • TLS
  • Translesion DNA synthesis

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