Human migraine models

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Abstract

The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.

Original languageEnglish
JournalCephalalgia : an international journal of headache
Volume21
Issue number7
Pages (from-to)781-5
Number of pages5
ISSN0333-1024
Publication statusPublished - Sep 2001

Keywords

  • Animals
  • Cerebrovascular Circulation
  • Humans
  • Migraine Disorders
  • Models, Neurological
  • Nitroglycerin
  • Vasodilator Agents

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