Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

Anna Cecilia Jørgensen; Anette Seo Torstenson

doi:10.1080/10837450801949384

Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

Anna Cecilia Jørgensen, Anette Seo Torstenson

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Abstract

The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

Original language	English
Journal	Pharmaceutical Development and Technology
Volume	13
Issue number	3
Pages (from-to)	187-95
Number of pages	8
ISSN	1083-7450
DOIs	https://doi.org/10.1080/10837450801949384
Publication status	Published - 2008

Bibliographical note

Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction

Keywords

Former Faculty of Pharmaceutical Sciences

Access to Document

10.1080/10837450801949384

Cite this

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title = "Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration",

abstract = "The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.",

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note = "Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction",

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language = "English",

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AU - Jørgensen, Anna Cecilia

AU - Torstenson, Anette Seo

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PY - 2008

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N2 - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

AB - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1080/10837450801949384

DO - 10.1080/10837450801949384

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SN - 1083-7450

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EP - 195

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