Humoral response to two doses of BNT162b2 vaccination in people with HIV

Line Dam Heftdal; Andreas Dehlbæk Knudsen; Sebastian Rask Hamm; Cecilie Bo Hansen; Dina Leth Møller; Mia Pries-Heje; Kamille Fogh; Rasmus Bo Hasselbalch; Ida Jarlhelt; Laura Pérez-Alós; Linda Maria Hilsted; Sisse Rye Ostrowski; Jan Gerstoft; Kirsten Grønbæk; Henning Bundgaard; Kasper Iversen; Peter Garred; Susanne Dam Nielsen

doi:10.1111/joim.13419

Humoral response to two doses of BNT162b2 vaccination in people with HIV

Line Dam Heftdal^*, Andreas Dehlbæk Knudsen, Sebastian Rask Hamm, Cecilie Bo Hansen, Dina Leth Møller, Mia Pries-Heje, Kamille Fogh, Rasmus Bo Hasselbalch, Ida Jarlhelt, Laura Pérez-Alós, Linda Maria Hilsted, Sisse Rye Ostrowski, Jan Gerstoft, Kirsten Grønbæk, Henning Bundgaard, Kasper Iversen, Peter Garred, Susanne Dam Nielsen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

25 Downloads (Pure)

Abstract

Background: People with HIV (PWH) are at increased risk of severe COVID-19. We aimed to determine humoral responses in PWH and controls who received two doses of BNT162b2. Methods: In 269 PWH and 538 age-matched controls, we measured IgG and neutralizing antibodies specific for the receptor-binding domain of SARS-CoV-2 at baseline, 3 weeks and 2 months after the first dose of BNT162b2. Results: IgG antibodies increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the concentrations of IgG antibodies were lower in PWH than that in controls at 3 weeks and 2 months (p = 0.025 and <0.001), respectively. The IgG titres in PWH with a humoral response at 2 months were 77.9% (95% confidence interval [62.5%–97.0%], age- and sex-adjusted p = 0.027) of controls. Conclusions: Reduced IgG antibody response to vaccination with BNT162b2 was found in PWH, and thus increased awareness of breakthrough infections in PWH is needed.

Original language	English
Journal	Journal of Internal Medicine
Volume	291
Issue number	4
Pages (from-to)	513-518
ISSN	0954-6820
DOIs	https://doi.org/10.1111/joim.13419
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2021 The Association for the Publication of the Journal of Internal Medicine

Keywords

antibody response
BNT162b2
HIV
SARS-CoV-2
vaccine

Access to Document

10.1111/joim.13419

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Cite this

Heftdal, L. D., Knudsen, A. D., Hamm, S. R., Hansen, C. B., Møller, D. L., Pries-Heje, M., Fogh, K., Hasselbalch, R. B., Jarlhelt, I., Pérez-Alós, L., Hilsted, L. M., Ostrowski, S. R., Gerstoft, J., Grønbæk, K., Bundgaard, H., Iversen, K., Garred, P., & Nielsen, S. D. (2022). Humoral response to two doses of BNT162b2 vaccination in people with HIV. Journal of Internal Medicine, 291(4), 513-518. https://doi.org/10.1111/joim.13419

Humoral response to two doses of BNT162b2 vaccination in people with HIV. / Heftdal, Line Dam; Knudsen, Andreas Dehlbæk; Hamm, Sebastian Rask; Hansen, Cecilie Bo; Møller, Dina Leth; Pries-Heje, Mia; Fogh, Kamille; Hasselbalch, Rasmus Bo; Jarlhelt, Ida; Pérez-Alós, Laura; Hilsted, Linda Maria ; Ostrowski, Sisse Rye ; Gerstoft, Jan ; Grønbæk, Kirsten ; Bundgaard, Henning ; Iversen, Kasper ; Garred, Peter ; Nielsen, Susanne Dam.

In: Journal of Internal Medicine, Vol. 291, No. 4, 2022, p. 513-518.

Research output: Contribution to journal › Journal article › Research › peer-review

Heftdal, LD, Knudsen, AD, Hamm, SR, Hansen, CB, Møller, DL, Pries-Heje, M, Fogh, K, Hasselbalch, RB, Jarlhelt, I, Pérez-Alós, L, Hilsted, LM , Ostrowski, SR , Gerstoft, J , Grønbæk, K , Bundgaard, H , Iversen, K , Garred, P & Nielsen, SD 2022, 'Humoral response to two doses of BNT162b2 vaccination in people with HIV', Journal of Internal Medicine, vol. 291, no. 4, pp. 513-518. https://doi.org/10.1111/joim.13419

Heftdal, Line Dam ; Knudsen, Andreas Dehlbæk ; Hamm, Sebastian Rask ; Hansen, Cecilie Bo ; Møller, Dina Leth ; Pries-Heje, Mia ; Fogh, Kamille ; Hasselbalch, Rasmus Bo ; Jarlhelt, Ida ; Pérez-Alós, Laura ; Hilsted, Linda Maria ; Ostrowski, Sisse Rye ; Gerstoft, Jan ; Grønbæk, Kirsten ; Bundgaard, Henning ; Iversen, Kasper ; Garred, Peter ; Nielsen, Susanne Dam. / Humoral response to two doses of BNT162b2 vaccination in people with HIV. In: Journal of Internal Medicine. 2022 ; Vol. 291, No. 4. pp. 513-518.

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abstract = "Background: People with HIV (PWH) are at increased risk of severe COVID-19. We aimed to determine humoral responses in PWH and controls who received two doses of BNT162b2. Methods: In 269 PWH and 538 age-matched controls, we measured IgG and neutralizing antibodies specific for the receptor-binding domain of SARS-CoV-2 at baseline, 3 weeks and 2 months after the first dose of BNT162b2. Results: IgG antibodies increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the concentrations of IgG antibodies were lower in PWH than that in controls at 3 weeks and 2 months (p = 0.025 and <0.001), respectively. The IgG titres in PWH with a humoral response at 2 months were 77.9% (95% confidence interval [62.5%–97.0%], age- and sex-adjusted p = 0.027) of controls. Conclusions: Reduced IgG antibody response to vaccination with BNT162b2 was found in PWH, and thus increased awareness of breakthrough infections in PWH is needed.",

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AU - Møller, Dina Leth

AU - Pries-Heje, Mia

AU - Fogh, Kamille

AU - Hasselbalch, Rasmus Bo

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AU - Pérez-Alós, Laura

AU - Hilsted, Linda Maria

AU - Ostrowski, Sisse Rye

AU - Gerstoft, Jan

AU - Grønbæk, Kirsten

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N2 - Background: People with HIV (PWH) are at increased risk of severe COVID-19. We aimed to determine humoral responses in PWH and controls who received two doses of BNT162b2. Methods: In 269 PWH and 538 age-matched controls, we measured IgG and neutralizing antibodies specific for the receptor-binding domain of SARS-CoV-2 at baseline, 3 weeks and 2 months after the first dose of BNT162b2. Results: IgG antibodies increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the concentrations of IgG antibodies were lower in PWH than that in controls at 3 weeks and 2 months (p = 0.025 and <0.001), respectively. The IgG titres in PWH with a humoral response at 2 months were 77.9% (95% confidence interval [62.5%–97.0%], age- and sex-adjusted p = 0.027) of controls. Conclusions: Reduced IgG antibody response to vaccination with BNT162b2 was found in PWH, and thus increased awareness of breakthrough infections in PWH is needed.

AB - Background: People with HIV (PWH) are at increased risk of severe COVID-19. We aimed to determine humoral responses in PWH and controls who received two doses of BNT162b2. Methods: In 269 PWH and 538 age-matched controls, we measured IgG and neutralizing antibodies specific for the receptor-binding domain of SARS-CoV-2 at baseline, 3 weeks and 2 months after the first dose of BNT162b2. Results: IgG antibodies increased from baseline to 3 weeks and from 3 weeks to 2 months in both groups, but the concentrations of IgG antibodies were lower in PWH than that in controls at 3 weeks and 2 months (p = 0.025 and <0.001), respectively. The IgG titres in PWH with a humoral response at 2 months were 77.9% (95% confidence interval [62.5%–97.0%], age- and sex-adjusted p = 0.027) of controls. Conclusions: Reduced IgG antibody response to vaccination with BNT162b2 was found in PWH, and thus increased awareness of breakthrough infections in PWH is needed.

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