Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): Classification of a danish patient cohort according to EAACI/ENDA guidelines

Christoffer V. Nissen, Carsten Bindslev-Jensen, Charlotte G. Mortz*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

27 Citations (Scopus)

Abstract

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are reported to be the second most common cause of drug hypersensitivity. In 2011, experts from the EAACI/ENDA group and GA2LEN proposed a new classification system for NSAID hypersensitivity. The aim of this study was to classify a patient cohort with a history of NSAID hypersensitivity according to this system. Methods: Patients with a clinical history of NSAID hypersensitivity referred to the Allergy Centre, Odense University Hospital between 2002 and 2011 and evaluated with oral provocation tests (OPTs) were included in the study. Medical records were retrospectively investigated with respect to the culprit NSAID(s), underlying diseases and symptoms at the primary reaction and during oral provocation tests (OPTs). Data was supplemented with a questionnaire. Classification according to EAACI guideline was based on these findings. Results: In total 149 patients were included. Of those, 39 patients (26.2%) had a positive OPT. Twenty-nine patients were classified as cross-reactive responders and 9 patients as single NSAID responders after positive OPTs with the culprit NSAID, but not to acetylsalicylic acid. All single NSAID responders reacted to non-pyrazolone drugs. Only one patient could not be classified according to the EAACI/ENDA system. An overlap between respiratory and cutaneous symptoms was found in 15/39 (38%) of patients. Conclusions: All but one of our patients could be classified according to the EAACI classification system. Overlaps between different classes may occur much more commonly than expected

Original languageEnglish
Article number10
JournalClinical and Translational Allergy
Volume5
Issue number1
ISSN2045-7022
DOIs
Publication statusPublished - 3 Mar 2015

Bibliographical note

Publisher Copyright:
© 2015 Nissen et al.; licensee BioMed Central .

Keywords

  • Classification
  • Drug allergy
  • Hypersensitivity
  • Non-steroidal anti-inflammatory drugs
  • Provocation test

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