IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes

L Fugger; N Morling; K Bendtzen; L Ryder; V Andersen; C Heilman; F Karup Pedersen; J Friis; P Halbert; A Svejgaard

IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes

L Fugger, N Morling, K Bendtzen, L Ryder, V Andersen, C Heilman, F Karup Pedersen, J Friis, P Halbert, A Svejgaard

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation between the two marker systems. The two IL-6 RFLP's were studied in Danish patients with rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, and systemic lupus erythematosus. The frequencies of the MspI and BglII marker phenotypes did not differ between healthy controls and the three disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.

Original language	English
Journal	Journal of Immunogenetics
Volume	16
Issue number	6
Pages (from-to)	461-5
Number of pages	4
ISSN	0305-1811
Publication status	Published - 1989
Externally published	Yes

Bibliographical note

Keywords: Arthritis, Juvenile Rheumatoid; Arthritis, Rheumatoid; DNA; Denmark; Gene Frequency; Genetic Markers; Humans; Interleukin-6; Lupus Erythematosus, Systemic; Phenotype; Polymorphism, Restriction Fragment Length

Cite this

@article{38c10b10b1d511df825b000ea68e967b,

title = "IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes",

abstract = "The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation between the two marker systems. The two IL-6 RFLP's were studied in Danish patients with rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, and systemic lupus erythematosus. The frequencies of the MspI and BglII marker phenotypes did not differ between healthy controls and the three disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.",

author = "L Fugger and N Morling and K Bendtzen and L Ryder and V Andersen and C Heilman and {Karup Pedersen}, F and J Friis and P Halbert and A Svejgaard",

note = "Keywords: Arthritis, Juvenile Rheumatoid; Arthritis, Rheumatoid; DNA; Denmark; Gene Frequency; Genetic Markers; Humans; Interleukin-6; Lupus Erythematosus, Systemic; Phenotype; Polymorphism, Restriction Fragment Length",

year = "1989",

language = "English",

volume = "16",

pages = "461--5",

journal = "Journal of Immunogenetics",

issn = "0305-1811",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes

AU - Fugger, L

AU - Morling, N

AU - Bendtzen, K

AU - Ryder, L

AU - Andersen, V

AU - Heilman, C

AU - Karup Pedersen, F

AU - Friis, J

AU - Halbert, P

AU - Svejgaard, A

N1 - Keywords: Arthritis, Juvenile Rheumatoid; Arthritis, Rheumatoid; DNA; Denmark; Gene Frequency; Genetic Markers; Humans; Interleukin-6; Lupus Erythematosus, Systemic; Phenotype; Polymorphism, Restriction Fragment Length

PY - 1989

Y1 - 1989

N2 - The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation between the two marker systems. The two IL-6 RFLP's were studied in Danish patients with rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, and systemic lupus erythematosus. The frequencies of the MspI and BglII marker phenotypes did not differ between healthy controls and the three disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.

AB - The restriction enzymes MspI and BglII identify two different two-allele restriction fragment length polymorphisms (RFLP) in the human IL-6 genes of healthy Danes. Co-dominant segregation was demonstrated for both marker-systems and the test for Hardy-Weinberg equilibrium showed no significant deviation from expectations. There is a strong correlation between the two marker systems. The two IL-6 RFLP's were studied in Danish patients with rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, and systemic lupus erythematosus. The frequencies of the MspI and BglII marker phenotypes did not differ between healthy controls and the three disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.

M3 - Journal article

C2 - 2577114

SN - 0305-1811

VL - 16

SP - 461

EP - 465

JO - Journal of Immunogenetics

JF - Journal of Immunogenetics

IS - 6

ER -