Immune response and protection of cattle and pigs generated by a vaccinia virus recombinant expressing the F protein of rinderpest virus.

G. J. Belsham*, E. C. Anderson, P. K. Murray, J. Anderson, T. Barrett

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

38 Citations (Scopus)

Abstract

The immune response of cattle and pigs to a vaccinia recombinant virus containing the fusion (F) protein gene of rinderpest virus was examined. Half the cattle and all the pigs gave humoral response to primary vaccination and all the cattle gave an anamnestic response to a second vaccination 28 days after the primary vaccination. All the cattle after a single or secondary vaccination were completely protected clinically after exposure to a lethal dose of the Saudi 1/81 strain of virus. Prior vaccination with another TK- vaccinia recombinant (VVCAT) suppressed, but did not abrogate, the immune response to the rinderpest F recombinant. The pigs gave a humoral immune response in the absence of any local reaction at the site of vaccination.

Original languageEnglish
JournalThe Veterinary Record
Volume124
Issue number25
Pages (from-to)655-658
Number of pages4
ISSN0042-4900
DOIs
Publication statusPublished - 24 Jun 1989

Cite this